TABLE 2.

Pathological hallmarks of CCD and/or AD.

Abnormality	CCD	AD
Cognitive decline	+	+
Brain atrophy	+	+
Neuronal damage and death	+	+
Aβ accumulation in brain parenchyma	+	+
Diffuse Aβ plaques	+	+
Dense-core Aβ plaques	−	+
Aβ accumulation in blood vessel walls (CAA)	+	+
Neurofibrillary tangles (NTFs) formation	−	+
Microglial dysfunction	+	+
Astrocyte dysfunction	+	+
Astroglial hypertrophy and hyperplasia	+	+
Oxidative brain damage	+	+
Mitochondrial dysfunction	+	+
Cholinergic dysfunction	+	+
Impaired neuronal glucose metabolism	+	+