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σ1R, HINT1, and CaM binding to the transient receptor potential vanilloid member 1 (TRPV1) calcium channel. (A) Interactions between σ1R, CaM, and HINT1 with the TRPV1. The recombinant TRPV1 N-terminus (aa 1–433) and C-terminus (aa 680–839) (100 nM) were incubated with CaM, σ1R, and HINT1 (200 nM) in the presence or absence of 3 mM CaCl2. (B and C) Competition assays between the σ1R and CaM or HINT1 for their binding to the N- and C-terminal regions of TRPV1 (details as in Figure 1 ).
