Table 1.

Effect of sigma 1 receptor (σ1R) ligands on the association of σ1Rs with different signaling proteins.

Ligands	TRPA1 Nt	TRPA1 Ct	TRPV1 Nt	TRPV1 Ct	TRPM8 Nt	NR1 C0-C1	BiP
PregS	↓	↓	↓	↑	↑	↑ (a)	↓ (b)
PRE084	↓	↓	= *	↑	↑	↑ (a)	↓ (b)
ProG	↑	↓	=	↓	↓	↓ (a)	↑ (b)
S1RA	↑	↓	↑	↓	↓	↓ (a)	–

The arrows ↑ and ↓ indicate the enhancement or reduction in σ1R-target protein associations, while = denotes no change in such associations, *even though the ligand does not alter the σ1R–TRP interaction, the disruptive effect of pregnenolone sulfate (PregS) was impaired. References reporting the effects of σ1R ligands on the σ1R–NR1 or σ1R–binding immunoglobulin protein (BiP) interactions: (a) Rodríguez-Muñoz et al., 2015b, Antioxid. Redox Signal. 22: 799–818; (b) Hayashi and Su, 2007, Cell 131: 596–610.

PregS, pregnenolone sulfate; ProG, progesterone; BiP, binding immunoglobulin protein.