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. 2019 May 10;47(11):5511–5521. doi: 10.1093/nar/gkz352

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© The Author(s) 2019. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 1. — DNA mimics design. (A) Formulae of amino acid monomers Q^Pho, ^mQ^Pho and Q^5Pho. (B) Formulae of ^mQ^PhoQ^Pho and ^mQ^PhoQ^5Pho repeat units. (C–E) Top views and side views of molecular models of the structures of: (C) an eight-base-pair B-DNA; (D) (^mQ^PhoQ^Pho)₈ and (E) (^mQ^PhoQ^5Pho)₈. Phosphorus atoms are shown as large spheres. The same color code is used in (D) and (E) as in the formulae shown in (A). (F–I) Surface rendering showing negative charges (in red) of the structures of B-DNA (F), DNA mimic proteins TAFII230 (G) and HI1450 (H) and (^mQ^PhoQ^5Pho)₈ (I). All structures are shown at the same scale. The structures of B-DNA, HI1450 (PDB# 1NNV) (28) and TAFII230 (PDB# 1TBA) (29) are derived from crystal data. The structure of (^mQ^PhoQ^5Pho)₈ is an energy minimized model.