Table 1.
Inhibition of Top1 and HIV-1 IN by anionic foldamers 1–6. IC50 values (concentrations of each DNA mimic that induce 50% inhibition of the catalytic activity) and standard deviations were extracted from Figure 7A and B. nd: not determined due to the lack of inhibitory activity in the range of concentration investigated
| IC50 (μM) | ||
|---|---|---|
| Top1 | HIV-1 IN | |
| 1 (mQPhoQPho)8 | 0.225 ± 0.04 | 2.0 ± 0.4 |
| 2 (mQOAcQOAc)8 | nd. | nd. (>10) |
| 3 (mQOAcQ5Prop)8 | nd. | 2.2 ± 0.2 |
| 4 (mQAcQ5Ac)8 | nd. (activation) | nd. (activation) |
| 5 (mQButQ5But)8 | 0.83 ± 0.06 | 0.80 ± 0.02 |
| 6 (mQOAcQPho)8 | 0.94 ± 0.12 | 0.08 ± 0.03 |