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(A) Schematic representation of a guanine-rich RNA sequence (guanines as grey squares) under its random-coil (left) and folded, that is, quadruplex structures (G4, right). Detailed structures of guanine (left) and G-quartet (right). (B) Structure of both BioTASQ v.1 and v.2 (left) displaying a biotin affinity tag and schematic representation of its closed, G4-affinic conformation (right), in which the intramolecular G-quartet is formed.
