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Impact of the substitutions in the CysX motif (C665S/C668S) on Pol ϵ polymerase and exonuclease activity. Primer-extension assays in the presence of dNTPs and a DNA substrate with a fluorescently labeled 50-mer primer annealed to a perfectly matched 80-mer template. Exonuclease activity was assayed in the absence of dNTPs using the same double-stranded DNA substrate or only the single-stranded 50-mer.
