Table 2 –
Univariable (UVA) and multivariable (MVA) of Decipher adjusting for detectable prostate-specific antigen (PSA) and clinical data for prediction of metastasis for the overall cohort
| Variables | Category | UVA | MVA | ||
|---|---|---|---|---|---|
| HR (95% CI) | p value | HR (95% CI) | p value | ||
| Decipher risk (2 categories) | Low/intermediate | Ref | |||
| High | 7.71 (2.88–23.3) | <0.001 | 5.95 (2.02–19.4) | 0.001 | |
| Pre-operative PSAa | 1.55 (0.95–2.43) | 0.08 | 1.24 (0.79–1.92) | 0.4 | |
| Group 1 & 2 | Ref | ||||
| RP grade groups | Group 3 | 3.04 (0.92–11.0) | 0.07 | 1.57 (0.45–5.95) | 0.5 |
| Group 4 & 5 | 5.1 (1.55–18.4) | 0.008 | 1.53 (0.42–6.06) | 0.5 | |
| Positive surgical margins | 3.76 (1.42–9.93) | 0.009 | 1.22 (0.4–4.05) | 0.7 | |
| Lymph node invasion | 9.74 (2.85–27.9) | <0.001 | 12.18 (2.46–70.7) | 0.003 | |
| T2 | Ref | ||||
| Pathological stage | T3a | 7.93 (1.73–75.19) | 0.006 | 4.74 (0.96–46.3) | 0.056 |
| T3b & T4 | 11.5 (2.59–108.4) | <0.001 | 4.6 (0.95–44.9) | 0.059 | |
| Detectable PSA | 2.36 (0.89–6.72) | 0.08 | 4.26 (1.16–21.8) | 0.03 | |
CI = confidence interval; HR = hazard ratio; Ref = reference; RP = radical prostatectomy.
a
Preoperative PSA values were log2 transformed.