Table 3 –
Univariable (UVA) and multivariable (MVA) of Decipher adjusting for clinical data for prediction metastasis among detectable prostate-specific antigen (PSA) patients
| Variables | Category | UVA | MVA | ||
|---|---|---|---|---|---|
| HR (95% CI) | p value | HR (95% CI) | p value | ||
| Decipher risk (2 categories) | Low/intermediate | Ref | |||
| High | 7.23 (2.17–26.3) | 0.002 | 5.61 (1.48–22.7) | 0.01 | |
| Pre-operative PSAa | 2.26 (1.35–3.69) | 0.003 | 1.62 (0.98–2.74) | 0.062 | |
| Group 1 & 2 | Ref | ||||
| RP grade groups | Group 3 | 3.96 (0.88–22.7) | 0.07 | 2.69 (0.52–18.7) | 0.2 |
| Group 4 & 5 | 5.49 (1.21–31.6) | 0.028 | 1.78 (0.28–12.8) | 0.5 | |
| Positive surgical margins | 0.71 (0.19–3.75) | 0.6 | 0.85 (0.19–5.04) | 0.8 | |
| T2 | Ref | ||||
| Pathological stage | T3a | 3.4 (0.63–33.9) | 0.2 | 1.57 (0.21–18.2) | 0.7 |
| T3b & T4 | 4 (0.80–39.1) | 0.10 | 1.27 (0.18–14.6) | 0.8 | |
CI = confidence interval; HR = hazard ratio; RP = radical prostatectomy; Ref = reference.
a
Preoperative PSA values were log2 transformed. Since there were only two patients with lymph node invasion, it was not included in the MVA model