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. 2019 Mar 14;47(11):e61. doi: 10.1093/nar/gkz171

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© The Author(s) 2019. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Base excision repair enzyme activity is correlated between some, but not all, enzymes of the pathway in nuclear extracts of peripheral blood mononuclear cells from different individuals. (A) Uracil DNA glycosylase (UDG) activity was positively correlated with apurinic/apyrimidinic (AP) site incision activity (r = 0.61, P < 0.05). (B) UDG activity was not significantly correlated with DNA polymerase activity (r = 0.58, P = 0.053). (C) UDG activity was positively correlated with DNA ligase activity (r = 0.81, P < 0.001). (D) AP site incision activity was not significantly correlated with DNA polymerase activity (r = 0.40, P = 0.177). (E) AP site incision activity was positively correlated with DNA ligase activity (r = 0.73, P < 0.01). (F) DNA polymerase activity was positively correlated with DNA ligase activity (r = 0.67, P < 0.05).