Table 2.
Results of lung irradiation and the protective effect of melatonin
| Variable | Control | Melatonin-treated | Radiation | Radiation+Melatonin |
|---|---|---|---|---|
| Macrophage infiltration | 0.25 ± 50 | 0.25 ± 50 | 2.66 ± 0.57a | 0.80 ± 0.83b |
| Lymphocyte infiltration | 1.00 ± 0.80 | 0.50 ± 0.57 | 3.00 ± 00a | 0.60 ± 0.54b |
| Mast cell infiltration | 0.00 ± 00 | 1.00 ± 50 | 4.00 ± 00a | 3.50 ± 0.50 |
| Neutrophil infiltration | 0.50 ± 0.57 | 0.50 ± 0.57 | 0.00 ± 00 | 0.60 ± 0.54 |
| Alveolar thickness | 0.25 ± 50 | 0.25 ± 50 | 2.00 ± 1.00a | 0.20 ± 0.44b |
| Vascular thickness | 0.00 ± 00 | 0.00 ± 00 | 1.00 ± 00a | 0.00 ± 00b |
| Edema and thrombosis | 0.00 ± 00 | 0.00 ± 00 | 1.00 ± 0.57 | 0.00 ± 00 |
| Fibrosis | Absent | Absent | Mild | Absent |
Results were scored from 0-3 as 0; Normal, 1; Mild, 2; Severe, 3; Very severe, a; Significant compared to control group, and b; Significant compared to radiation group. Data are presented as mean ± SD.