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. 2018 Nov 20;19(24):2575–2583. doi: 10.1002/cbic.201800525

Figure 4.

Figure 4

A) Concept of a pulse‐chase NAIL‐MS assay to study the repair of methylated nucleosides by using isotope labeling to distinguish MMS‐damaged tRNAs (black, from medium A) and newly transcribed tRNAs (red, from medium B). B) Abundance of methylated nucleosides before MMS exposure, after 1 h of exposure to MMS, and after 24 h of recovery. Error bars represent the standard deviation of three biological replicates. P values of student t‐test are indicated as * p<0.05, ** p<0.01, *** p<0.005.