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. 2019 Jun 19;16:24. doi: 10.1186/s12014-019-9244-2

Table 3.

106 differential proteins associated with sperm function

Protein ID Protein name CS/C CV/C CV/CS
ACE Angiotensin-converting enzyme 0.59 0.48 N/A
ACR Acrosin 0.32 0.39 N/A
ACRBP Acrosin-binding protein N/A 0.49 N/A
ACSBG2 Long-chain-fatty-acid–CoA ligase ACSBG2 0.46 0.54 N/A
ACTR1A Alpha-centractin 0.27 0.18 N/A
AKAP3 A-kinase anchor protein 3 4.07 3.56 N/A
ARSA Arylsulfatase A 0.48 0.48 N/A
ATP5D ATP synthase subunit delta, mitochondrial N/A 1.68 N/A
ATP5H ATP synthase subunit d, mitochondrial 2.58 N/A 0.82
ATP5 J ATP synthase-coupling factor 6, mitochondrial 1.94 1.50 N/A
BSPH1 Binder of sperm protein homolog 1 N/A 0.40 0.45
C21orf33 ES1 protein homolog, mitochondrial N/A 0.45 0.49
C9orf9 Uncharacterized protein C9orf9 2.33 2.32 N/A
CABYR Calcium-binding tyrosine phosphorylation-regulated protein 0.31 N/A N/A
CALR Calreticulin 0.39 0.36 N/A
CCDC108 Coiled-coil domain-containing protein 108 N/A N/A N/A
CCDC136 Isoform 4 of Coiled-coil domain-containing protein 136 2.63 2.93 N/A
CCDC147 Coiled-coil domain-containing protein 147 2.35 2.30 N/A
COX4I1 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial 1.99 1.60 N/A
COX5B Cytochrome c oxidase subunit 5B, mitochondrial 2.60 2.34 N/A
COX6B1 Cytochrome c oxidase subunit 6B1 2.18 N/A N/A
CRISP2 Cysteine-rich secretory protein 2 0.59 N/A N/A
CTSG Cathepsin G N/A 0.64 N/A
CYCS Cytochrome c (Fragment) 5.40 3.19 1.25
CYLC2 Cylicin-2 N/A 2.07 N/A
DNALI1 Axonemal dynein light intermediate polypeptide 1 2.99 2.67 N/A
DPCD Protein DPCD 0.45 0.44 N/A
DPEP3 Dipeptidase 3 0.44 N/A N/A
DPY19L2 Probable C-mannosyltransferase DPY19L2 6.52 5.44 N/A
ELSPBP1 Epididymal sperm-binding protein 1 4.95 5.02 N/A
FKBP1A Peptidyl-prolyl cis–trans isomerase FKBP1A 0.47 N/A N/A
FSCN3 Fascin-3 4.63 3.88 N/A
FSIP2 Fibrous sheath-interacting protein 2 2.17 1.99 N/A
GNPDA1 Glucosamine-6-phosphate isomerase 1 N/A 0.33 N/A
HSF2BP Heat shock factor 2-binding protein 2.28 N/A N/A
HSP90B1 Endoplasmin 0.29 0.37 N/A
HSPA2 Heat shock-related 70 kDa protein 2 0.19 0.23 N/A
HSPA5 78 kDa glucose-regulated protein 0.29 0.36 N/A
IMMT Isoform 4 of Mitochondrial inner membrane protein 2.08 N/A N/A
KLHL10 Kelch-like protein 10 0.43 0.50 N/A
KRT9 Keratin, type I cytoskeletal 9 7.83 N/A N/A
LDHC L-lactate dehydrogenase C chain 0.16 0.19 N/A
MNS1 Meiosis-specific nuclear structural protein 1 N/A 0.48 N/A
MPC1L Mitochondrial pyruvate carrier 1-like protein N/A 2.74 N/A
MRPS36 28S ribosomal protein S36, mitochondrial N/A 0.53 N/A
NAMPT Nicotinamide phosphoribosyltransferase 0.43 0.70 1.47
NDUFA4 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 2.13 N/A N/A
NDUFS3 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial 1.67 N/A N/A
NUP62 Nuclear pore glycoprotein p62 0.48 0.39 N/A
OAZ3 Ornithine decarboxylase antizyme 3 2.83 3.14 N/A
PAFAH1B3 Platelet-activating factor acetylhydrolase IB subunit gamma N/A 0.49 N/A
PATE1 Prostate and testis expressed protein 1 2.08 2.11 N/A
PATE4 Prostate and testis expressed protein 4 2.09 1.99 N/A
PGAM2 Phosphoglycerate mutase 2 0.45 0.33 N/A
PGK1 Phosphoglycerate kinase 1 0.40 0.56 N/A
PGK2 Phosphoglycerate kinase 2 0.34 0.38 N/A
PHB2 Prohibitin-2 1.99 N/A N/A
PHGDH D-3-phosphoglycerate dehydrogenase N/A 2.20 N/A
PMFBP1 Isoform 2 of Polyamine-modulated factor 1-binding protein 1 4.38 3.82 N/A
PPP4R1 Serine/threonine-protein phosphatase 4 regulatory subunit 1 0.68 N/A N/A
PRDX4 Peroxiredoxin-4 N/A 0.41 N/A
PREP Prolyl endopeptidase 0.57 N/A N/A
PRKACA cAMP-dependent protein kinase catalytic subunit alpha 0.43 0.44 N/A
PRSS37 Probable inactive serine protease 37 0.39 N/A N/A
PRTN3 Myeloblastin N/A 0.66 N/A
PSMA1 Proteasome subunit alpha type-1 0.58 0.52 N/A
PSMA2 Proteasome subunit alpha type-2 0.32 0.31 N/A
PSMA3 Proteasome subunit alpha type-3 0.65 0.62 N/A
PSMA4 Proteasome subunit alpha type-4 0.40 0.38 N/A
PSMA5 Proteasome subunit alpha type-5 0.45 0.37 N/A
PSMB1 Proteasome subunit beta type-1 0.37 0.35 N/A
PSMB4 Proteasome subunit beta type-4 0.25 0.22 N/A
PSMB5 Proteasome subunit beta type-5 0.41 0.44 N/A
PSMB7 Proteasome subunit beta type-7 0.38 0.44 N/A
RAD23B UV excision repair protein RAD23 homolog B 0.22 0.31 N/A
RDH16 Retinol dehydrogenase 16 N/A 1.59 N/A
ROPN1B Ropporin-1B 4.20 N/A N/A
RUVBL1 RuvB-like 1 0.26 0.26 N/A
SEMG1 Semenogelin-1 N/A 0.55 0.55
SEPHS1 Selenide, water dikinase 1 0.44 0.59 N/A
SEPT4 Septin-4 1.73 N/A N/A
SLPI Antileukoproteinase 4.90 N/A N/A
SMCP Sperm mitochondrial-associated cysteine-rich protein N/A 3.08 N/A
SMRP1 Spermatid-specific manchette-related protein 1 1.55 N/A N/A
SOD1 Superoxide dismutase [Cu–Zn] 0.14 0.17 N/A
SPA17 Sperm surface protein Sp17 2.06 1.88 N/A
SPAG6 Isoform 3 of Sperm-associated antigen 6 2.53 N/A N/A
SPANXA1 Sperm protein associated with the nucleus on the X chromosome A N/A 5.43 N/A
SPANXB1 Sperm protein associated with the nucleus on the X chromosome B/F 3.95 4.14 N/A
SPATA6 Spermatogenesis-associated protein 6 3.98 N/A N/A
SPEM1 Spermatid maturation protein 1 2.69 2.13 N/A
SPINT3 Kunitz-type protease inhibitor 3 N/A 3.25 N/A
STOM Erythrocyte band 7 integral membrane protein N/A 0.50 N/A
TCP11 T-complex protein 11 homolog 2.06 N/A N/A
TEKT1 Tektin-1 2.18 N/A N/A
TEKT2 Tektin-2 4.35 2.86 1.16
TEKT3 Tektin-3 1.81 N/A N/A
TEKT4 Tektin-4 2.13 2.05 N/A
TEKT5 Tektin-5 N/A 2.32 N/A
TSGA10 Testis-specific gene 10 protein 10.58 9.59 N/A
TXNDC2 Thioredoxin domain-containing protein 2 0.41 0.37 N/A
VAT1 Synaptic vesicle membrane protein VAT-1 homolog 0.60 0.64 N/A
VDAC3 Voltage-dependent anion-selective channel protein 3 2.41 N/A N/A
WFDC8 WAP four-disulfide core domain protein 8 3.12 2.39 N/A
ZPBP1 Zona pellucida-binding protein 1 N/A 0.41 N/A
ZPBP2 Zona pellucida-binding protein 2 0.42 0.54 N/A

CS/C, The fold of change between cryostraw (CS) and control (C); CV/C, The fold of change between cryovial (CV) and control (C); CV/CS, The fold of change between cryovial (CV) and cryostraw (CS)