Table 1.
Top transcripts in patients with metastatic lung cancer based on hierarchical clustering
| Genes | Plasma detection | CTC detection |
|---|---|---|
| CCL5 | A,B,C | B |
| CLU | A,B,C | B |
| GPX1 | A,B,C | B |
| AKT3 | A,B,C | |
| ARHGDIB | A,B,C | |
| SPARC | A,B,C | |
| SRGN | A,B,C | |
| TNXB | A,B,C | |
| THBS1 | B,C | B |
| BAI1 | B,C | |
| CLDN1 | B,C | |
| EGF | B,C | |
| FHL1 | B,C | |
| PDK1 | B,C | |
| PLEKHO1 | B,C | |
| RBL1 | B,C | |
| RBX1 | B,C | |
| TGFB1 | B,C | |
| GIMAP4 | B | B |
| ITGB3 | C | C |
| PECAM1 | C | B |
| LRG1 | B,C | |
| PKN1 | B,C |
Only genes satisfying at least two cutoff criteria are shown. A, genes consistently showing higher expression based on plasma and CTC analyses; B and C, first and second tier of rare cancer-specific events. See Material and Methods for details. Bold face, genes forming a tight (confidence score > 0.9) cluster by interaction analysis using String database