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. 2019 Jun 18;19:149. doi: 10.1186/s12872-019-1120-5

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Talin-1 is downregulated in the fibrous cap of unstable carotid plaque. a Western blot for Talin-1 expression in human carotid plaque (n = 3 per group). Talin-1 was significantly downregulated in unstable carotid plaque (P < 0.05). b qRT-PCR for Talin-1 expression in human carotid plaque (n = 10 per group). Talin-1 was significantly downregulated in unstable carotid plaque (P < 0.05). c Immunofluorescent on the same sections (n = 3) of carotid plaque with Talin-1 staining (n = 10 per group). Quantitative analysis of the results of immunofluorescent revealed that Talin-1 is distributed in the fibrous cap of carotid plaque and its content was significantly downregulated in unstable carotid plaque (P < 0.05). Data are represented as mean ± SD. n = 6 randomly chosen fields in each group