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. 2019 Jun 18;12:347. doi: 10.1186/s13104-019-4389-7

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Effects of TAE226 on signaling pathways and tumor growth in MIA PaCa-2 models. a Effects of TAE226 on phosphorylation of FAK at Y397, Akt at S473 and ERK1/2 in MIA PaCa-2 cells treated for 1 h. b Effects of TAE226 on phosphorylation of FAK at Y397, Akt at S473 and ERK1/2 in MIA PaCa-2 tumors. Tumor samples were collected 3 h after administration of TAE226 at doses of 10, 30 and 100 mg/kg. Two or three animals were used for each group and each lane represents an individual animal. c Effects of TAE226 on MIA PaCa-2 subcutaneous tumor growth (n = 7). Tumor volume was calculated according to the formula: length × width²/2. d Effects of TAE226 on MIA PaCa-2 orthotopic tumor growth (n = 8). Values are expressed by mean ± SEM. Gemcitabine was administered intravenously twice weekly