Table 4.

Multivariate Cox regression analysis for the overall survival and relapse-free survival of osteosarcoma patients

Characteristics	OS		RFS
	HR (95% CI)	P	HR (95% CI)	P
Distant metastasis, presence (vs. absence)	9.669 (1.994–46.879)	0.005	6.577 (1.524–28.377)	0.012
Cy-FAM83H, positive (vs. negative)	15.463 (3.196–74.809)	< 0.001	15.825 (3.461–72.358)	<  0.001

Abbreviations: Cy-FAM83H cytoplasmic expression of FAM83H, HR hazard ratio, 95% CI 95% confidence interval. The multivariate analysis was adjusted for age, tumor size, stage, histologic grade, lymph node metastasis, distant metastasis, nuclear FAM83H expression, cytoplasmic FAM83H expression, and β-catenin expression. HR hazard ratio, OS overall survival, RFS relapse-free survival