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. 2019 Jun 12;9:491. doi: 10.3389/fonc.2019.00491

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Copyright © 2019 Gong, Wen, Li, Xin, Che, Wang, Liu and Qu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DYNC1I1 regulates IL-6 expression by promoting NF-KB nuclear transport. (A) RT-qPCR shows IL-6 transcription level after knocking down DYNC1I1 gene or overexpression DYNC1I1. (B) Website predicts IL-6 classical transcription factor (https://www.genecards.org/). (C) GEPIA website analysis the correlation between RELA(P65) and IL-6 in gastric cancer. (D) Nucleoplasm separation shows the distribution of P65 and P-P65 in the cytoplasm after knocking down DYNC1I1 or overexpression of DYNC1I1. (E) Immunoprecipitation shows the binding of P65 to DYNC1I1 in cells. (^**P < 0.01, ^****P < 0.0001, n = 3, student t-test, means ± 95% CI).