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HDAC inhibitor (SAHA) restores DOX sensitivity in DOXR cells. (a) mRNA expression of HIST1H2BK and HIST1H1C in WT and DOXR cells. Significance compared with WT for each gene. (b) DOX sensitivity of WT and DOXR cells cultured with or without SAHA for 5 days. ∗p < 0.05, two-tailed Student's t-test. Significance compared with DOXR and DOXR/SAHA0.01 at 0.1 μM DOX. CON = control.
