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Molecular mechanism related to pharmacological effects of A. orientale regulating lipid and glucose metabolism in liver. A. orientale stimulated adiponectin and subsequently suppressed hepatic de novo lipogenesis and accelerated fatty acid oxidation via AMPK and PPARα activation, resulting in decreased hepatic TG contents and lipid output acceleration from liver. In addition, A. orientale regulated hepatic gluconeogenesis by lowering PEPCK and G6Pase mRNA via AMPK-SREBP1c signaling.
