Table 1. P-CAFs fibroblasts co-grafted with 144epi mammary carcinoma cells promotes tumor invasion.
144epi cells were transplanted alone, or with NAFs or P-CAFs for 60 days. Tumor samples stained by H&E were scored for invasiveness. Statistical analysis was performed by Chi-square test for trend. Statistical significance was determined by p<0.05. p<0.0001. n=8 for 144epi alone, n=9 for 144epi: NAF, n=8 for 144epi: P-CAF.
| non- invasive |
lowly- invasive |
highly invasive |
|
|---|---|---|---|
| Alone | 8 | 0 | 0 |
| NAF | 5 | 2 | 2 |
| P-CAF | 1 | 1 | 6 |