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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: J Physiol. 2019 May 22;597(12):3085–3105. doi: 10.1113/JP277856

Figure 11. CM4620 diminishes the oxidative burst induced by fMLF peptide in human neutrophils.

Figure 11.

Neutrophils isolated from human blood were pretreated for 30 min with DMSO (as control) or CM4620 and then superoxide anion formation was stimulated with fMLF (A-B) or PMA (C) and measured for 4 h using the chemiluminescence LumiMax (R) superoxide anion measurement kit (Agilent Technologies, La Jolla, CA) following manufacturer’s instructions. CM4620 significantly inhibits fMLF-induced superoxide production (P<0.001; Two-way ANOVA). Data in graph are mean ± SD; n=2 independent experiments. (B) Graph shows area under the curve (AUC) for traces depicted in (A). (C) CM4620 does not affect the oxidative burst induced by PMA in human neutrophils. Data in graph are mean ± SD; n=3 independent experiments.