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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: J Physiol. 2019 May 22;597(12):3085–3105. doi: 10.1113/JP277856

Figure 3. CM4620 decreases cell death and trypsin activity in pancreatic acini.

Figure 3.

(A) Freshly isolated rodent and human acini were pretreated with 3 μM CM4620 for 30 min and then treated with toxic doses of CCK or TLCS for 3 h. Cell death was estimated by measuring propidium iodide (PI) intake into the cells. Graphs show mean ± SEM, n=3 independent cell preparations. (B) Pancreatic acini were pretreated with 3 μM CM4620 for 30 min and then treated with CCK, TLCS or carbachol (CCh) for 1 h. Trypsin activity was measured by enzymatic chromogenic assay. Graph shows mean ± SEM; n=3–4 independent cell preparations.