Figure 4. CM4620 administration significantly reduces pancreatitis responses in mouse cerulein acute pancreatitis.

Pancreatitis was induced in mice by supramaximal cerulein administration (50 μg/kg, 7 hourly IP injections); saline-treated mice were used as controls (−). CM4620 (20 mg/kg) or vehicle control were administered intraperitoneally 30 min before the 1^st and 4^th cerulein injection; blood and tissues were collected 1 h after the last cerulein injection. Graphs show levels of amylase (A) and lipase (B) in blood, and trypsin activity in pancreatic tissue homogenates. Data in graphs are mean ± SD of the values from of 3 mice per group.