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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: J Physiol. 2019 May 22;597(12):3085–3105. doi: 10.1113/JP277856

Figure 9. Prophylactic administration of CM4620 to rats ameliorates severity of acute pancreatitis.

Figure 9.

Cerulein acute pancreatitis was induced in rats as indicated in Figure 3B. Cerulein or saline control (−) were administered as 4 hourly IP injections, and CM4620 (20 mg/kg) or vehicle control as a 4-h continuous intravenous (IV) infusion into the jugular vein. The IV infusion was initiated 2 h before the first cerulein injection, and blood and tissue samples were collected 2 h after the end of the infusion period. (A). Graph shows quantitative analyses (mean ± SD; n=3 rats per group) for pancreatic injury scored in H&E stained tissue sections following the score system indicated in Material and Methods. Graphs in (B) and (C) show levels of pancreatic trypsin and myeloperoxidase activities, respectively. Data in graphs are mean ± SD, n=3 rats/group.