. Author manuscript; available in PMC: 2020 Jun 1.

Published in final edited form as: J Physiol. 2019 May 22;597(12):3085–3105. doi: 10.1113/JP277856

Table 2.

IC₅₀ values for CM4620 on cytokine release by human peripheral blood mononuclear cells (PBMC)^*

Cytokines	CM4620 Replicate IC₅₀Values in nM (mean)
IFNγ	175, 102 (138)
IL-1β	264, 217 (240)
IL-2	71, 47 (59)
IL-4	952, 807 (879)
IL-6	145, 126 (135)
IL-10	367, 239 (303)
IL-17	140, 100 (120)
TNFα	278, 173 (225)

Cells were stimulated with plate-bound anti-CD3/anti-CD28 in 10% FBS for 48 h.