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Timeline of clinical course. Chronology of major clinical events and lines of therapy along the glioblastoma (GBM) disease course. Gold boxes indicate surgeries, gray boxes show radiation therapy (RT) and systemic treatment, and the red box indicates response to targeted therapy. Resected specimens are labeled A to D. IDO, indoleamine 2,3-dioxygenase; R, right. (†) Patient death.
