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. Author manuscript; available in PMC: 2019 Jun 19.
Published in final edited form as: Cell Rep. 2019 May 21;27(8):2249–2261.e7. doi: 10.1016/j.celrep.2019.04.078

Table 2.

Model Parameters Used in MSN Computations Shown in Figure 4

S τ(V)





Current Gate g¯ (nS.μm−2) Vs (mV) ks (mV) τ0 (ms) Vτ (mV) kτ (mV)
INat mNat3, hNat 1.61 See STAR Methods
INap mNap 3.1e−3 −47.8 3.1 1.0 - -
INas mNas 0.02 −16.0 9.4 637.8 −33.5 26.3
IKDR nKDR4 0.11 See STAR Methods
IKIR mKIR 0.33e−3 −100 −10
IKRP mKRP 0.155 −13.4 12.1 206.2 −53.9 26.5
hKRP −55.0 −19.0 See STAR Methods
IKAf mKAf 0.0017 −33.1 7.5 1.0
hKAf −70.4 −7.6 25.0
IKAS mKAS 6.7e−6 −25.6 13.3 131.4 −37.4 27.3
hKAS −78.8 −10.4 See STAR Methods

Full details are in the STAR Methods. Here, PNa, leak = 1.96e−7, PCl, leak = 1.5e−7, and PK, leak = 0.6e−7(μm/ms). The equilibrium potentials for Na+, K+ and Cl were 56.64 mV, −87.06 mV, and −95.07 mV at 295.15 K, respectively, and were calculated using the Nernst equation for each ion with concentrations identical to those used in the experiments.