Table 2.
Model Parameters Used in MSN Computations Shown in Figure 4
S∞ | τ(V) | ||||||
---|---|---|---|---|---|---|---|
Current | Gate | (nS.μm−2) | Vs (mV) | ks (mV) | τ0 (ms) | Vτ (mV) | kτ (mV) |
INat | , hNat | 1.61 | See STAR Methods | ||||
INap | mNap | 3.1e−3 | −47.8 | 3.1 | 1.0 | - | - |
INas | mNas | 0.02 | −16.0 | 9.4 | 637.8 | −33.5 | 26.3 |
IKDR | 0.11 | See STAR Methods | |||||
IKIR | mKIR | 0.33e−3 | −100 | −10 | – | – | – |
IKRP | mKRP | 0.155 | −13.4 | 12.1 | 206.2 | −53.9 | 26.5 |
hKRP | −55.0 | −19.0 | See STAR Methods | ||||
IKAf | mKAf | 0.0017 | −33.1 | 7.5 | 1.0 | – | – |
hKAf | −70.4 | −7.6 | 25.0 | – | – | ||
IKAS | mKAS | 6.7e−6 | −25.6 | 13.3 | 131.4 | −37.4 | 27.3 |
hKAS | −78.8 | −10.4 | See STAR Methods |
Full details are in the STAR Methods. Here, PNa, leak = 1.96e−7, PCl, leak = 1.5e−7, and PK, leak = 0.6e−7(μm/ms). The equilibrium potentials for Na+, K+ and Cl− were 56.64 mV, −87.06 mV, and −95.07 mV at 295.15 K, respectively, and were calculated using the Nernst equation for each ion with concentrations identical to those used in the experiments.