Table 3. OR (95% CI) Associations Between Prenatal Urinary Phthalate Metabolite Levels and Language Delay in Children in SELMA.
| Compound | OR (95% CI) | |||||
|---|---|---|---|---|---|---|
| Crudea | Adjustedb | Adjusted for all Covariates and Sex × Exposure | Stratification and Adjustmentd | |||
| Adjusted for All Covariates and Interaction Termc | P Value for Interaction Term | Boys (n = 508)d | Girls (n = 455)d | |||
| MEP | 1.16 (1.02-1.33) | 1.14 (1.00-1.31) | 1.28 (1.04-1.64) | .29 | 1.09 (0.93-1.29) | 1.29 (1.00-1.66) |
| MBP | 1.33 (1.07-1.67) | 1.29 (1.03-1.63) | 1.30 (0.85-2.01) | .99 | 1.31 (1.00-1.71) | 1.23 (0.79-1.92) |
| MBzP | 1.29 (1.10-1.51) | 1.26 (1.07-1.49) | 1.08 (0.81-1.45) | .59 | 1.39 (1.13-1.71) | 1.04 (0.76-1.41) |
| MEHP | 0.91 (0.77-1.09) | 0.90 (0.75-1.09) | 0.80 (0.58-1.10) | .34 | 0.99 (0.78-1.24) | 0.78 (0.56-1.08) |
| MEHHP | 0.91 (0.76-1.10) | 0.89 (0.73-1.09) | 0.79 (0.55-1.13) | .41 | 0.97 (0.76-1.23) | 0.76 (0.51-1.10) |
| MEOHP | 0.97 (0.89-1.18) | 0.95 (0.77-1.18) | 0.78 (0.53-1.15) | .21 | 1.07 (0.83-1.38) | 0.74 (0.50-1.12) |
| MECPP | 0.91 (0.76-1.10) | 0.89 (0.73-1.09) | 0.81 (0.58-1.15) | .50 | 0.95 (0.75-1.21) | 0.77 (0.53-1.12) |
| MCMHP | 0.86 (0.70-1.06) | 0.86 (0.69-1.08) | 0.79 (0.52-1.19) | .60 | 0.90 (0.69-1.18) | 0.76 (0.49-1.17) |
Abbreviations: MBP, monobutyl phthalate; MBzP, monobenzyl phthalate; MCMHP, mono(2-carboxymethylhexyl) phthalate; MECPP, mono(2-ethyl-5-carboxypentyl) phthalate; MEHP, mono(2-ethylhexyl) phthalate; MEHHP, mono(2-ethyl-5-hydroxyhexyl) phthalate; MEOHP, mono(2-ethyl-5-oxohexyl) phthalate; MEP, monoethyl phthalate; OR, odds ratio; SELMA, Swedish Environmental Longitudinal Mother and Child, Asthma and Allergy.
Model 1: adjusted for the creatinine level in urine.
Model 2: adjusted for the creatinine level in urine; sex; preterm birth; mother’s educational level; and mother’s smoking status and weight at study enrollment.
Model 3: adjusted for the creatinine level in urine; sex; preterm birth; mother’s educational level; and mother’s smoking status and weight at study enrollment as well as the interaction term (sex × exposure).
Adjusted for the creatinine level in urine; preterm birth; mother’s educational level; and mother’s smoking status and weight at study enrollment.