Table 2. Workup and Surgery Characteristics and Length of Stay of Non–Screen-Detected and Screen-Detected Colorectal Cancera,b.
| Characteristic | Colon | Rectum | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Not Screen Detected, No. (%) | P Value: Not Screen Detected 2014-2016 vs 2011-2013 | Screen Detected, 2014-2016, No. (%) | P Value: Screen Detected (2014-2016) vs Not Screen Detected(2014-2016) | Not Screen Detected, No. (%) | P Value: Not Screen Detected 2014-2016 vs 2011-2013 | Screen Detected, 2014-2016, No. (%) | P Value: Screen Detected (2014-2016) vs Not Screen Detected (2014-2016) | |||
| 2011-2013 | 2014-2016 | 2011-2013 | 2014-2016 | |||||||
| Total patients, No. | 15 610 | 15 936 | NA | 4696 | NA | 7898 | 7936 | NA | 1582 | NA |
| Workup | ||||||||||
| Entire visualization of colon | 12202 (79) | 13221 (83) | <.001 | 4354 (93) | <.001 | 6707 (86) | 6864 (87) | .11 | 1494 (95) | <.001 |
| Discussed in MDT | 13386 (87) | 15053 (95) | <.001 | 4537 (97) | <.001 | 7715 (98) | 7828 (99) | .001 | 1563 (99) | .65 |
| Neoadjuvant chemotherapy | 308 (2) | 374 (2) | .02 | 27 (0.6) | <.001 | NA | NA | NA | NA | NA |
| Neoadjuvant radiotherapyc | ||||||||||
| No | 15481 (99) | 15850 (100) | .02 | 4684 (100) | .01 | 1401 (18) | 2926 (37) | <.001 | 1005 (64) | <.001 |
| SCRT-IS | 37 (0.2) | 17 (0.1) | 5 (0.1) | 2924 (37) | 1354 (17) | 286 (18) | ||||
| SCRT-DS | 77 (0.5) | 65 (0.4) | 7 (0.1) | 528 (7) | 769 (10) | 46 (3) | ||||
| CRT/long course | 15 (0.1) | 4 (0) | 0 | 3045 (39) | 2887 (36) | 245 (16) | ||||
| Procedure | ||||||||||
| Ileocecal resection | 169 (1) | 101 (0.6) | <.001 | 12 (0.3) | <.001 | NA | NA | <.001 | NA | <.001 |
| Right hemicolectomy | 7251 (48) | 7713 (49) | 1656 (36) | NA | NA | NA | ||||
| Transversectomy | 404 (3) | 359 (2) | 83 (2) | NA | NA | NA | ||||
| Left hemicolectomy | 1588 (10) | 1606 (10) | 623 (13) | NA | NA | NA | ||||
| Sigmoid resection | 5815 (38) | 5834 (37) | 2271 (49) | NA | NA | NA | ||||
| (Low) anterior resection | NA | NA | NA | 5197 (66) | 5214 (66) | 1148 (73) | ||||
| Abdominoperineal resection | NA | NA | NA | 2289 (29) | 2165 (27) | 214 (14) | ||||
| Other | NA | NA | NA | 353 (5) | 511 (7) | 213 (14) | ||||
| Surgical approach | ||||||||||
| Open | 6849 (44) | 3732 (24) | <.001 | 527 (11) | <.001 | 3365 (43) | 1450 (18) | <.001 | 136 (9) | <.001 |
| Laparoscopic | 8735 (56) | 12142 (76) | 4150 (89) | 4278 (54) | 6034 (76) | 1247 (79) | ||||
| Otherd | 11 (0) | 9 (0) | 6 (0) | 249 (3.2) | 433 (6) | 196 (12) | ||||
| No laparoscopic conversion | 7184 (86) | 10454 (88) | .004 | 3719 (92) | <.001 | 3499 (86) | 5236 (91) | <.001 | 1087 (92) | .230 |
| Additional resection due to tumor invasion | ||||||||||
| No | 14107 (90) | 14441 (91) | .74 | 4589 (98) | <.001 | 7380 (93) | 7283 (92) | <.001 | 1551 (98) | <.001 |
| Yes, limited | 859 (6) | 860 (5) | 66 (1) | 240 (3) | 317 (4) | 22 (1) | ||||
| Yes, extensive | 644 (4) | 635 (4) | 41 (0.9) | 278 (4) | 336 (4) | 9 (0.6) | ||||
| Additional resection due to metastasis | 585 (4) | 661 (4) | .07 | 83 (2) | <.001 | 226 (3) | 253 (3) | .23 | 11 (0.7) | <.001 |
| Stomac | ||||||||||
| No | 13947 (90) | 14572 (92) | <.001 | 4534 (97) | <.001 | 1316 (17) | 2066 (27) | <.001 | 609 (43) | <.001 |
| End colostomy | 778 (5) | 754 (5) | 56 (1) | 3442 (45) | 3065 (41) | 331 (23) | ||||
| Other | 739 (5) | 562 (4) | 90 (2) | 2864 (38) | 2422 (32) | 473 (34) | ||||
| Unknown | 16 (0.1) | 13 (0.1) | 3 (0.1) | 9 (0.1) | 5 (0.1) | 0 (0) | ||||
| Completeness of Resection | ||||||||||
| Radical resectionc | ||||||||||
| R0 | 14944 (98) | 15620 (98) | <.001 | 4658 (100) | <.001 | 7273 (96) | 7199 (95) | .03 | 1380 (98) | <.001 |
| R1 | 258 (2) | 215 (1) | 21 (0.4) | 266 (4) | 335 (4) | 31 (2) | ||||
| R2 | 121 (0.8) | 42 (0.3) | 3 (0.1) | 27 (0.4) | 11 (0.1) | 0 (0) | ||||
| Circumferential margin, positive (≤1 mm) | NA | NA | NA | NA | NA | 464 (7) | 406 (5) | .006 | 37 (2) | <.001 |
| Median lymphe nodes removed, median (IQR) | 15 (12-21) | 18 (13-24) | <.001f | 16 (12-22) | <.001f | 12 (9-17) | 15 (11-20) | <.001f | 15 (11-19) | <.001f |
| Positive lymph node ratio, %c | 9.0 | 7.8 | <.001 | 5.7 | <.001 | 8.6 | 6.8 | <.001 | 4.9 | <.001 |
| Length of stay, median (IQR), d | 6 (5-10) | 6 (4-9) | <.001f | 5 (4-7) | <.001f | 8 (6-13) | 7 (5-11) | <.001f | 5 (4-9) | <.001f |
Abbreviations: CRT, chemoradiotherapy; IQR, interquartile range; MDT, multidisciplinary team meeting; NA, not applicable; SCRT-DS, short-course radiotherapy with delayed surgery; SCRT-IS, short-course radiotherapy with immediate surgery.
Missing per category are reported in eTable 2 in the Supplement. All missing were 10% or less.
χ2 Test was used for all categorical variables.
Analysis by χ2 was done for different subgroups than shown in this Table (because of low number [<5] of cases in 1 or more subcategory) for neoadjuvant radiotherapy (categorized into yes vs no neoadjuvant radiotherapy), stoma (unknown was excluded for analysis), and radical resection (R0 vs R1-2).
Other surgical approach (eg, local excision, transanal endoscopic microsurgery, single-port transanal surgery).
Excluded for rectum were the local excisions (total patients analyzed: non–screen-detected rectum, 2011 to 2013, n = 7652; 2014 to 2016, n = 7565; and screen-detected rectum, 2014-2016, n = 1415).
Mann-Whitney U test.