Table 3. Clinical Characteristics, DCIS Lesion Features, and Therapy Received Among Patients With Radiotherapy Based on the DCIS Scorea.
| Variable | Radiotherapy Recommendation Based on DCIS Score (n = 171) | Low DCIS Score (<39) (n = 82) | Intermediate-High DCIS Score (≥39) (n = 89) | P Valueb |
|---|---|---|---|---|
| Age, median (range), y | 60 (36-87) | 59 (40-80) | 61 (36-87) | .98 |
| Longest diameter, median (IQR), mm | 11 (6-19) | 10 (6-15.5) | 11 (6-20) | .29 |
| DCIS gradec | ||||
| Low nuclear | 16 (9.4) | 14 (17.1) | 2 (2.2) | <.001 |
| Intermediate nuclear | 65 (38.0) | 46 (56.1) | 19 (21.3) | |
| High nuclear | 89 (52.0) | 21 (25.6) | 68 (76.4) | |
| Not reported or unknown | 1 (0.6) | 1 (1.2) | 0 | |
| ER or PR status | ||||
| ER positive or PR positive | 138 (80.7) | 72 (87.8) | 66 (74.2) | .006 |
| ER negative and PR negative | 17 (9.9) | 2 (2.4) | 15 (16.9) | |
| Unknown | 16 (9.4) | 8 (9.8) | 8 (9.0) | |
| Radiotherapy course based on DCIS score | ||||
| Yes | 91 (53.2) | 7 (8.5) | 84 (94.4) | <.001 |
| No | 80 (46.8) | 75 (91.5) | 5 (5.6) | |
| Endocrine treatment | ||||
| Yes | 110 (64.3) | 61 (74.4) | 49 (55.1) | .02 |
| No | 46 (26.9) | 16 (19.5) | 30 (33.7) | |
| Not reported | 15 (8.8) | 5 (6.1) | 10 (11.2) |
Abbreviations: DCIS, ductal carcinoma in situ; ER, estrogen receptor; IQR, interquartile range; PR, progesterone receptor.
a
Data are presented as number (percentage) of patients unless otherwise indicated.
b
P values are from the nonparametric Wilcoxon rank sum test for continuous variables and the exact Pearson χ2 test for categorical variables. For the comparison of DCIS grade, the category not reported or unknown is excluded; for the comparison of endocrine treatment, the category not reported is excluded.
c
Reported DCIS grade corresponds to the highest-order DCIS grade identified at the patient level from the initial diagnostic core needle biopsy through the final surgical procedure.