. 2018 Nov 7;75(12):1261–1269. doi: 10.1001/jamapsychiatry.2018.3039

Table 2. Set-Based Association Results on Gene Sets in the Whole-Exome Sequencing Discovery and Follow-up Stages^a.

Gene Set (No. of Genes)	Discovery				Follow-up
	No. of Variants	P Value	Q Value		Allele Count, NR; BR	No. of Variants	P Value
	No. of Variants	P Value	B-H Method	Histogram Method	Allele Count, NR; BR	No. of Variants	P Value
MGI: reduced NMDA-mediated synaptic currents (13)	49	.001	0.0495^b	0.0463	42; 19^b	261	.009
MGI: reduced AMPA-mediated synaptic currents (17)	43	.001	0.0495^b	0.0463	36; 14^b	231	.11
MGI: abnormal AMPA-mediated synaptic currents (12)	20	.012	0.2544^b	0.2375	17; 6^b	78	.67

Abbreviations: AMPA, α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid; B-H, Benjamin-Hochberg; BR, best responder; MGI, Mouse Genome Informatics; NMDA, N-methyl-D-aspartate; NR, nonresponder.

^{^a}

Rare nonsynonymous variants predicted to be damaging with a minor allele frequency lower than 1% were included in this analysis.

^{^b}

P < .05 indicates statistically significant associations.

Table 2. Set-Based Association Results on Gene Sets in the Whole-Exome Sequencing Discovery and Follow-up Stagesa.

Table 2. Set-Based Association Results on Gene Sets in the Whole-Exome Sequencing Discovery and Follow-up Stages^a.