Table 1. Baseline Characteristics of Women Included in the Primary Per-Protocol Analysis.
| Characteristics | Glyburide Group (n = 367) | Insulin Group (n = 442) |
|---|---|---|
| Age, mean (SD), y | 32.5 (5.1) | 32.6 (5.3) |
| Multiparity, No. (%) | 216 (58.9) | 293 (66.3) |
| Prepregnancy BMI, mean (SD)a | 27.3 (5.5) | 27.8 (5.8) |
| BMI at diagnosis, mean (SD)a | 30.7(5.1) | 31.1(5.4) |
| Geographical origin, No. (%) | ||
| Europe | 146 (41.3) | 184 (43.2) |
| North Africa | 124 (34.9) | 136 (31.9) |
| Sub-Saharan Africa | 35 (9.9) | 50 (11.7) |
| Asia | 19 (5.4) | 21 (4.9) |
| Other | 31 (8.7) | 35 (8.2) |
| Previous gestational diabetes, No. (%) | 73 (20.0) | 88 (19.9) |
| Gestational age, median (IQR), wk+d | ||
| At OGTT screening | 26+5 (25+3 to 28+0) | 26+3 (25+1 to 28+0) |
| At treatment | 32+6 (30+6 to 34+3) | 32+3 (30+3 to 34+1) |
| Type of blood glucose measurement with abnormal result at randomization, No. (%) | ||
| Only fasting | 12 (3.3) | 13 (2.9) |
| Only 2-h postprandial | 65 (17.7) | 72 (16.3) |
| Both fasting and 2-h postprandial | 290 (79.0) | 357 (80.8) |
| Proportion of abnormal blood glucose results at randomization, median (IQR)b | ||
| Fasting blood glucose ≥95 mg/dL | 0.3 (0.1-0.6) | 0.3 (0.1-0.5) |
| Postprandial blood glucose ≥120 mg/dL | 0.2 (0.1-0.3) | 0.2 (0.1-0.3) |
Abbreviations: IQR, interquartile range; OGTT, oral glucose tolerance test.
a
Body mass index (BMI) is calculated as weight in kilograms divided by height in meters squared.
b
For each woman, the number of abnormal blood glucose assay results over all of her blood glucose assays between inclusion and randomization was computed, then medians and IQRs of these proportions were calculated.