A 10-year risk threshold of 7.5% captures 4.5 million individuals (45%) who are at high long-term benefit, while also including 900 000 at lower benefit (maximum number needed to treat at 30 years, 17). Reducing the 10-year risk threshold to 5% captures 7.8 million individuals (79%) at high benefit, while also including 4.0 million at lower benefit (maximum number needed to treat at 30 years, 27). A 2.5% 10-year risk threshold captures all 9.9 million (100%) at high benefit, but also includes 13.8 million at lower benefit (maximum number needed to treat at 30 years, 34).