Table 2. Discordance in Characteristics of Individuals Recommended for Lipid-Lowering Treatment, Stratified by Benefit Level.
| Characteristic | Patients, No. (%) | |||
|---|---|---|---|---|
| Recommended Based on Neither Benefit | Recommendation With 10-y Benefit ≥2.3% Only | Recommendation With 30-y Benefit ≥15% Only | Recommended Based on Both Benefits | |
| Total | 1341 (79.4) | 40 (2.4) | 82 (4.9) | 225 (13.3) |
| Representation of US population | 45.9 million (81.2) | 800 000 (1.4) | 3.3 million (5.9) | 6.6 million (11.6) |
| Age, median (interquartile range), y | 48 (47-48) | 56 (54-57) | 50 (48-52) | 53 (52-54) |
| Women, No. (%) [95% CI] | 818 (61) [58-63] | 9 (22) [10-34] | 35 (43) [26-59] | 34 (15) [10-20] |
| Clinical findings, mean (95% CI) | ||||
| Low-density lipoprotein cholesterol, mg/dL | 117 (115-118) | 110 (103-118) | 149 (142-155) | 147 (143-151) |
| High-density lipoprotein cholesterol, mg/dL | 58 (57-59) | 60 (53-68) | 46 (43-50) | 45 (44-47) |
| Triglycerides, mg/dL | 107 (102-112) | 96 (75-117) | 158 (138-179) | 160 (143-177) |
| Systolic blood pressure, mm Hg | 116 (115-117) | 134 (127-141) | 128 (124-132) | 130 (127-134) |
| Antihypertensive therapy, No. (%) [95% CI] | 148 (11) [10-13] | 9 (23) [10-36] | 29 (35) [19-51] | 63 (28) [19-37] |
| Cigarette smoking, No. (%) [95% CI] | 188 (14) [11-17] | 20 (49) [27-71] | 28 (34) [18-50] | 119 (53) [43-62] |
| Risk calculations, mean % (95% CI) | ||||
| 10-y Risk | 2.0 (1.9-2.1) | 9.3 (8.3-10.2) | 4.7 (4.4-5.1) | 9.6 (8.9-10.3) |
| 30-y Risk | 12.6 (12.2-13.0) | 26.2 (25.0-27.4) | 27.7 (26.7-28.7) | 36.7 (34.8-38.7) |
| 30-y Absolute risk reduction | 6.8 (6.6-7.0) | 13.2 (12.7-13.7) | 17.0 (16.5-17.5) | 22.5 (21.1-23.8) |
SI conversion factors: To convert cholesterol to millimoles per liter, multiply by 0.0259. To convert triglycerides to millimoles per liter, multiply by 0.0113.