Table 1. Comparison of Patients With Moderate vs Severe Aortic Stenosis (AS) at Baseline.
| Variable | Mean (SD) | P Value | ||
|---|---|---|---|---|
| All (N = 1375) | Moderate AS (n = 514) | Severe AS (n = 861) | ||
| Age, y | 71 (13) | 68 (13) | 72 (12) | <.001 |
| Male, No. (%) | 834 (60.7) | 337 (65.6) | 497 (57.7) | .004 |
| Height, cm | 167 (9) | 168 (9) | 166 (9) | .04 |
| Weight, kg | 75 (15) | 78 (15) | 73 (16) | <.001 |
| Body surface area, m2 | 1.8 (0.2) | 1.9 (0.2) | 1.8 (0.2) | <.001 |
| Systolic blood pressure, mm Hg | 140 (19) | 140 (18) | 140 (20) | .97 |
| Diastolic blood pressure, mm Hg | 78 (11) | 78 (10) | 77 (11) | .41 |
| Hypertension, No. (%) | 833 (60.6) | 327 (63.6) | 506 (58.8) | .07 |
| Diabetes, No. (%) | 245 (17.8) | 95 (18.4) | 150 (17.4) | .74 |
| Smoker, No. (%) | 415 (30.1) | 180 (35.0) | 235 (27.3) | .002 |
| Dyslipidemia, No. (%) | 722 (52.5) | 299 (58.1) | 423 (49.1) | <.001 |
| Chronic obstructive pulmonary disease, No. (%) | 104 (7.6) | 48 (9.3) | 56 (6.5) | .03 |
| β-Blockers, No. (%) | 482 (35.1) | 150 (29.2) | 332 (38.6) | <.001 |
| Angiotensin-converting enzyme inhibitor, No. (%) | 447 (32.5) | 177 (34.4) | 270 (31.4) | .31 |
| LV mass, g/m2 | 207 (73) | 209 (58) | 206 (81) | .51 |
| LVESV, mL | 39 (21) | 40 (22) | 39 (20) | .53 |
| LVEDV, mL | 103 (34) | 110 (35) | 100 (33) | <.001 |
| SV index, mL/m2 | 44 (11) | 46 (11) | 42 (11) | <.001 |
| LV ejection fraction, % | 65.5 (7.4) | 66 (6.9) | 65 (7.3) | .003 |
| Peak aortic velocity, m/s | 3.8 (0.8) | 3.3 (0.7) | 4.1 (0.7) | <.001 |
| Mean aortic pressure gradient, mm Hg | 37 (17) | 26 (12) | 44 (16) | <.001 |
| Aortic valve area, cm2 | 0.94 (0.3) | 1.20 (0.2) | 0.78 (0.1) | <.001 |
| Mitral E wave velocity, cm/s | 87 (28) | 84 (22) | 88 (31) | .02 |
| Mitral E/A ratio | 1 (0.6) | 1 (0.4) | 1 (0.6) | .80 |
| E/e’ ratio | 10.8 (5.7) | 10.6 (4.6) | 10.9 (6.4) | .28 |
Abbreviations: EDV, end-diastolic volume; ESV, end-systolic volume; LV, left ventricular; SV, stroke volume.