Figure 4. Subgroup Analyses of Primary Outcome Composite of Death or Major Disability.

Box sizes correspond to precision; therefore, the more precise the larger the box. Precision was ascertained by calculating the inverse of the variance for each estimate. Spo₂ indicates oxygen saturation as measured by pulse oximetry.

^aDenominators include the total number of infants with a known outcome.

^bExcluded 74 infants in the Canadian Oxygen Trial who were exposed to both the original and revised software.

^cInborn defined as born inside the treating center; outborn, born outside the treating center (eg, transferred from another hospital).

^dLess than 10th percentile using charts from Kramer et al.²⁸