Table 1. Characteristics of Study Participants.
| Variable | Participants, No. (%) | P Value | |
|---|---|---|---|
| Without β-Amyloid Deposits | With β-Amyloid Deposits | ||
| Total | 148 | 1055 | NA |
| Age at death, mean (SD), y | 87.0 (7.0) | 89.7 (6.4) | <.001a |
| Education, mean (SD), y | 16.6 (3.7) | 16.1 (3.6) | .13a |
| Female | 84 (56.8) | 734 (69.6) | .002b |
| Non-Latino white individuals | 141 (95.3) | 1008 (95.6) | .84b |
| APOE ε4 carriers | 9 (6.1) | 298 (28.5) | <.001b |
| Dementia | 37 (25.0) | 496 (47.1) | <.001b |
| Pathologic AD per NIA Reagan criteria | 0 | 775 (73.5) | <.001c |
| Paired helical filament tau tangle density, median (IQR) | |||
| Total | 1.75 (0.60-3.32) | 4.77 (2.06-10.12) | <.001d |
| Neocortical | 0.04 (0.005-0.17) | 0.59 (0.05-3.77) | <.001d |
| Mesial temporal | 6.41 (2.32-12.99) | 16.08 (7.50-28.88) | <.001d |
| Macroscopic infarcts | 49 (33.1) | 386 (36.6) | .41b |
| Microinfarcts | 35 (23.7) | 325 (30.8) | .08b |
| Cortical Lewy bodies | 19 (12.9) | 135 (12.8) | .97b |
| TDP pathology | |||
| No inclusions | 94 (67.1) | 459 (45.4) | <.001b |
| Inclusions in amygdala | 25 (17.9) | 200 (19.8) | |
| Inclusions extend to limbic regions | 13 (9.3) | 208 (20.6) | |
| Inclusions extend to neocortical regions | 8 (5.7) | 144 (14.2) | |
| Hippocampal sclerosis | 8 (5.4) | 103 (9.8) | .08b |
| Cerebral amyloid angiopathy | |||
| None | 77 (54.6) | 182 (17.5) | <.001b |
| Mild | 51 (36.2) | 446 (42.8) | |
| Moderate | 9 (6.4) | 258 (24.7) | |
| Severe | 4 (2.8) | 157 (15.0) | |
| Atherosclerosis | |||
| None | 25 (17.0) | 198 (18.8) | .70b |
| Mild | 66 (44.9) | 506 (48.1) | |
| Moderate | 44 (29.9) | 274 (26.0) | |
| Severe | 12 (8.2) | 75 (7.1) | |
| Arteriolosclerosis | |||
| None | 48 (32.9) | 304 (29.0) | .67b |
| Mild | 49 (33.6) | 393 (37.4) | |
| Moderate | 39 (26.7) | 267 (25.4) | |
| Severe | 10 (6.8) | 86 (8.2) | |
Abbreviations: AD, Alzheimer disease; APOE, apolipoprotein E; IQR, interquartile range; NA, not applicable; NIA, National Institute on Aging; TDP, transactive response DNA-binding protein.
a
By t test.
b
By χ2 test.
c
By Fisher exact test.
d
By Wilcoxon rank sum test.