Table 3. Associations of β-Amyloid Protein With Neuropathologic Conditions in the Absence of β-Amyloid Depositsa.
| Neuropathologic Outcome | Age | Male | Education | β-Amyloid | ||||
|---|---|---|---|---|---|---|---|---|
| Estimate (SE) | P Value | Estimate (SE) | P Value | Estimate (SE) | P Value | Estimate (SE) | P Value | |
| Paired helical filament tau tangles | 0.012 (0.005) | .02 | −0.218 (0.073) | .003 | −0.016 (0.010) | .09 | 0.009 (0.019) | .63 |
| Macroscopic infarcts | 0.043 (0.027) | .11 | 0.393 (0.387) | .31 | −0.078 (0.052) | .13 | 0.027 (0.100) | .79 |
| Microinfarcts | 0.008 (0.030) | .78 | 0.747 (0.433) | .08 | −0.136 (0.060) | .02 | 0.064 (0.112) | .57 |
| Cortical Lewy bodies | 0.026 (0.037) | .48 | 0.411 (0.548) | .45 | 0.0004 (0.071) | >.99 | 0.161 (0.123) | .19 |
| TDP-43 | 0.101 (0.029) | <.001 | 0.136 (0.398) | .73 | −0.036 (0.053) | .50 | 0.083 (0.095) | .38 |
| Hippocampal sclerosis | 0.052 (0.057) | .36 | 0.353 (0.863) | .68 | −0.050 (0.117) | .67 | 0.286 (0.158) | .07 |
| Amyloid angiopathy | −0.011 (0.026) | .66 | 0.859 (0.373) | .02 | −0.080 (0.049) | .10 | 0.324 (0.095) | <.001 |
| Atherosclerosis | 0.005 (0.023) | .84 | 0.233 (0.330) | .48 | −0.090 (0.044) | .04 | 0.026 (0.087) | .77 |
| Arteriolosclerosis | 0.019 (0.023) | .41 | 0.022 (0.327) | .95 | −0.111 (0.044) | .01 | 0.045 (0.087) | .60 |
Abbreviation: TDP, transactive response DNA binding protein.
a
The results were obtained using linear (for continuous outcomes) or logistic (for binary or ordinal outcomes) regression models in which individual neuropathologic measures are the outcomes. Each row represents a separate regression model for different neuropathologic outcomes. Numbers presented are estimates (with SEs) and P values for the association of each independent variable (age, sex, education, and β-amyloid protein) with the neuropathologic outcome.