Table 2. Mean Change in Health-Related Quality of Life, as Measured by St George’s Respiratory Questionnaire, at 6 Months After Discharge by Study Groupa.
| Measure | Intervention | Usual Care | Adjusted Difference, Mean Change (95% CI)b |
P Valuec | ||||
|---|---|---|---|---|---|---|---|---|
| Mean (SD) Score | Change in Score, Mean (95% CI) | Mean (SD) Score | Change in Score, Mean (95% CI) | |||||
| Baseline | At 6 mo | Baseline | At 6 mo | |||||
| Co-primary Outcomed | ||||||||
| Total score | 64.0 (17.8) | 62.5 (22.1) | −1.53 (−5.20 to 2.14) |
62.8 (18.9) | 68.3 (23.2) | 5.44 (0.82 to 10.05) |
−6.69 (−12.97 to −0.40) |
.04 |
| Post Hoc Outcomesd | ||||||||
| Symptom score | 67.1 (20.4) | 61.6 (23.9) | −5.54 (−10.59 to −0.49) |
64.7 (22.1) | 68.0 (24.2) | 3.32 (−2.40 to 9.03) |
−7.16 (−13.39 to −0.93) |
.04 |
| Activity score | 83.0 (17.4) | 79.2 (21.9) | −3.72 (−7.67 to 0.22) |
80.3 (20.8) | 82.1 (21.2) | 1.82 (−2.64 to 6.28) |
−4.57 (−11.67 to 2.53) |
.13 |
| Impact score | 52.1 (21.5) | 52.6 (26.2) | 0.50 (−3.62 to 4.63) |
52.1 (22.2) | 60.3 (27.8) | 8.23 (2.77 to 13.70) |
−7.87 (−15.37 to −0.38) |
.04 |
St George’s Respiratory Questionnaire measures health-related quality of life for patients with respiratory disease; provides a total score and 3 domain scores for symptom, activity, and impact (measuring respiratory symptoms, ability to do physical activity, and impact of illness on life, respectively); and the score range for total and domain scores is 0 (best) to 100 (worst), with a 4-point difference being clinically meaningful.17,18,19,20,21
Adjusted for hospital enrollment unit and St George’s Respiratory Questionnaire score at baseline. Negative numbers suggest the intervention group did better.
Analysis completed with linear regression. Normality of residuals was good. There was no evidence of heteroskedasticity of residuals with respect to group (P = .34, >.99, .85, and .15 for total, symptom, activity, and impact scores, respectively).
Data were available for patients as follows: Total score: n = 94 in usual care, n = 94 in intervention; symptom score: n = 94 in usual care, n = 97 in intervention; activity score: n = 94 in usual care, n = 94 in intervention; and impact score: n = 94 in usual care, n = 96 in intervention.