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. 2018 May 15;319(19):2009–2020. doi: 10.1001/jama.2018.5690

Table 2. Trends in Prevalence of Use of Any Prescription Medication and 2 or More Prescription Medications in Prior 30 Days, by Sex, Age Group, and Race or Hispanic Origin: Children and Adolescents Aged 0 to 19 Years, United States, 1999-2014a.

1999-2002
(n = 10 706)
2003-2006
(n = 10 441)
2007-2010
(n = 8530)
2011-2014
(n = 8600)
β (95% CI)b P Value for Trendb
Unweighted No. Prevalence, % (95% CI) Unweighted No. Prevalence, % (95% CI) Unweighted No. Prevalence, % (95% CI) Unweighted No. Prevalence, % (95% CI)
Use of Any Prescription Medication
Overall 2203 24.6 (22.6 to 26.6) 2188 24.8 (22.8 to 26.9) 1836 24.6 (23.0 to 26.3) 1651 21.9 (20.3 to 23.6) −0.41 (−0.79 to −0.03) .04
Age
0-23 mo 406 25.5 (21.8 to 29.6) 370 24.0 (20.7 to 27.5) 338 24.1 (20.6 to 27.8) 229 17.4 (14.9 to 20.1) −1.14 (−1.79 to −0.49) <.001
2-5 y 332 19.5 (16.3 to 23.1) 373 21.1 (17.1 to 25.7) 377 20.0 (17.7 to 22.4) 309 16.5 (13.7 to 19.7) −0.52 (−1.17 to 0.14) .12
6-11 y 433 22.0 (18.5 to 25.9) 427 23.0 (19.5 to 26.8) 548 24.3 (21.2 to 27.7) 532 21.5 (19.2 to 24.0) 0.09 (−0.64 to 0.82) .81
12-19 y 1032 28.8 (26.5 to 31.1) 1018 28.0 (25.3 to 30.9) 573 27.3 (24.2 to 30.6) 581 25.9 (22.6 to 29.4) −0.58 (−1.16 to 0.00) .05
Sex
Boys 1143 25.7 (23.1 to 28.4) 1078 24.5 (21.8 to 27.5) 965 23.8 (21.9 to 25.8) 859 20.6 (18.5 to 22.9) −0.69 (−1.18 to −0.21) .006
Girls 1060 23.4 (21.5 to 25.5) 1110 25.1 (23.2 to 27.0) 871 25.5 (22.6 to 28.5) 792 23.3 (20.7 to 25.9) −0.12 (−0.60 to 0.36) .63
Race and Hispanic originc
Non-Hispanic white 831 28.3 (25.4 to 31.4) 812 28.6 (25.8 to 31.5) 759 29.1 (26.8 to 31.5) 505 25.3 (22.6 to 28.2) −0.41 (−1.02 to 0.21) .20
Non-Hispanic black 537 18.1 (16.2 to 20.1) 621 19.4 (17.1 to 21.8) 385 21.1 (19.0 to 23.4) 474 21.1 (18.6 to 23.7) 0.52 (0.06 to 0.98) .03
Mexican American 586 15.6 (14.1 to 17.1) 550 16.5 (14.7 to 18.4) 395 16.6 (14.1 to 19.3) 266 15.9 (12.9 to 19.2) −0.07 (−0.59 to 0.45) .79
Use of ≥2 Prescription Medications
Overall 796 9.3 (7.9 to 10.9) 847 9.9 (8.9 to 10.9) 700 9.3 (8.3 to 10.5) 638 8.5 (7.6 to 9.4) −0.17 (−0.40 to 0.06) .15
Age
0-23 mo 132 8.3 (6.5 to 10.3) 128 8.3 (6.6 to 10.3) 101 6.5 (4.5 to 9.0) 62 4.7 (3.6 to 6.0) −0.58 (−0.88 to −0.27) <.001
2-5 y 110 7.0 (5.2 to 9.3) 139 7.1 (5.5 to 9.0) 134 6.9 (5.6 to 8.5) 96 4.9 (3.4 to 6.8) −0.35 (−0.71 to 0.01) .06
6-11 y 167 7.4 (5.6 to 9.7) 177 9.6 (7.7 to 11.8) 223 9.3 (7.3 to 11.6) 238 8.6 (7.3 to 10.2) 0.21 (−0.16 to 0.58) .26
12-19 y 387 12.2 (10.6 to 14.0) 403 11.8 (10.4 to 13.3) 242 11.3 (9.6 to 13.2) 242 10.9 (9.1 to 12.8) −0.28 (−0.63 to 0.06) .11
Sex
Boys 403 9.4 (7.3 to 11.8) 436 9.8 (8.4 to 11.3) 385 9.4 (7.8 to 11.3) 361 8.7 (7.5 to 10.1) −0.04 (−0.38 to 0.30) .81
Girls 393 9.3 (7.9 to 10.8) 411 10.0 (9.0 to 11.1) 315 9.3 (7.9 to 10.8) 277 8.1 (6.9 to 9.5) −0.30 (−0.57 to −0.04) .03
Race and Hispanic originc
Non-Hispanic white 318 11.1 (9.1 to 13.3) 320 11.5 (10.2 to 12.9) 274 10.7 (9.2 to 12.4) 189 9.5 (8.1 to 11.0) −0.28 (−0.62 to 0.07) .12
Non-Hispanic black 181 6.4 (4.9 to 8.3) 250 8.0 (6.7 to 9.3) 154 8.5 (6.9 to 10.4) 202 9.2 (7.6 to 11.0) 0.44 (0.12 to 0.76) .009
Mexican American 199 5.0 (4.3 to 5.8) 199 6.1 (4.9 to 7.5) 155 6.7 (5.3 to 8.3) 104 6.6 (4.9 to 8.5) 0.22 (−0.06 to 0.50) .13
a

Source: National Center for Health Statistics, National Health and Nutrition Examination Survey, 1999-2014. Prevalence estimates are weighted to account for differential probabilities of selection and survey nonresponse.

b

The estimate (β), 95% CI, and P value were calculated using linear regression models that included the National Health and Nutrition Examination Survey 2-y cycle as a continuous variable. The estimate (β) can be interpreted as the average percentage point change in prevalence every 2 y.

c

Categories “other Hispanic” and “other” not shown.