Table 1. Combined and Sex-Stratified Multivariable-Adjusted Hazard Ratios (95% CIs) for CRC According to Quartiles of Chemerin Distribution and per Doubling in Chemerin Concentrationsa.
| Chemerin by Sex and Overall | Adjusted Hazard Ratio (95% CI) for CRC by Chemerin Distribution Quartile | Hazard Ratio (95% CI) per Doubling of Chemerin | ||||
|---|---|---|---|---|---|---|
| Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | P Value for Trendb | ||
| Chemerin, median (IQR), ng/mL | 111.6 (101.8-118.6) | 136.2 (130.3-141.8) | 157.3 (152.3-163.9) | 192.5 (180.8-210.4) | NA | NA |
| CRC Overall | ||||||
| No. of cases/noncases | 26/586 | 45/580 | 68/579 | 82/584 | NA | 221/2329 |
| Age- and sex-adjusted model | 1 [Reference] | 1.29 (0.78-2.12) | 2.00 (1.24-3.22) | 2.10 (1.30-3.37) | <.001 | 2.11 (1.35-3.29) |
| Model 2 | 1 [Reference] | 1.19 (0.71-1.99) | 1.94 (1.18-3.19) | 1.97 (1.19-3.25) | .001 | 2.04 (1.25-3.31) |
| Model 3 | 1 [Reference] | 1.17 (0.69-1.96) | 1.79 (1.08-2.96) | 1.81 (1.08-3.05) | .007 | 1.81 (1.09-3.00) |
| CRC by Men | ||||||
| No. of cases/noncases | 17/227 | 29/228 | 40/210 | 44/214 | NA | 130/879 |
| Age- and sex-adjusted model | 1 [Reference] | 1.22 (0.66-2.28) | 1.84 (1.00-3.39) | 1.85 (1.00-3.43) | .02 | 2.05 (1.06-3.95) |
| Model 2 | 1 [Reference] | 1.02 (0.53-1.97) | 1.51 (0.79-2.88) | 1.63 (0.83-3.21) | .07 | 2.03 (0.94-4.37) |
| Model 3 | 1 [Reference] | 0.92 (0.47-1.81) | 1.27 (0.65-2.47) | 1.41 (0.70-2.86) | .18 | 1.72 (0.78-3.80) |
| CRC by Women | ||||||
| No. of cases/noncases | 9/359 | 16/352 | 28/369 | 38/370 | NA | 91/1450 |
| Age- and sex-adjusted model | 1 [Reference] | 1.32 (0.58-3.02) | 2.14 (0.98-4.66) | 2.47 (1.15-5.29) | .005 | 2.37 (1.28-4.40) |
| Model 2 | 1 [Reference] | 1.28 (0.56-2.94) | 2.09 (0.95-4.59) | 2.46 (1.12-5.41) | .006 | 2.61 (1.31-5.20) |
| Model 3 | 1 [Reference] | 1.32 (0.57-3.06) | 2.05 (0.92-4.58) | 2.40 (1.07-5.42) | .01 | 2.54 (1.23-5.25) |
Abbreviations: CRC, colorectal cancer; IQR, interquartile range; NA, not applicable.
a
Continuous log-transformed chemerin concentrations by log 2. Model 2 includes age, sex, education, alcohol intake, smoking, physical activity, dietary factors (fruit, fish, fiber, dairy products, red and processed meat, whole-grain bread, and nonstarchy vegetables), body mass index, and waist circumference residually adjusted for body mass index. Model 3 is model 2 plus high-density lipoprotein cholesterol, hemoglobin A1c, and high-sensitivity C-reactive protein. P for interaction between sex and chemerin = .61.
b
P value for trend from a linear model, calculated using the median chemerin concentration within quartiles as a continuous variable.