Table 1. Child Demographic and Clinical Characteristics at Enrollment by Treatment Group.
| Characteristic | Children, No. (%) | ||
|---|---|---|---|
| Amoxicillin (n = 564) | Placebo (n = 562) | Overall (n = 1126) | |
| Age, mo | |||
| 2-11 | 196 (34.8) | 196 (34.9) | 392 (34.8) |
| 12-35 | 255 (45.2) | 254 (45.2) | 509 (45.2) |
| 36-59 | 113 (20.0) | 112 (19.9) | 225 (20.0) |
| Sex | |||
| Male | 271 (48.0) | 254 (45.2) | 525 (46.6) |
| Female | 293 (52.0) | 308 (54.8) | 601 (53.4) |
| Height/weight z scorea | |||
| <−3 | 0 | 1 (0.2) | 1 (0.1) |
| −2 to −3 | 5 (0.9) | 9 (1.6) | 14 (1.2) |
| >−2 | 558 (98.9) | 552 (98.2) | 1110 (98.6) |
| Mid–upper arm circumference, cma | |||
| <11.5 | 0 | 0 | 0 |
| 11.5-13.5 | 32 (5.7) | 45 (8.0) | 77 (6.8) |
| >13.5 | 531 (94.1) | 517 (92.0) | 1048 (93.1) |
| Respiratory rate, mean (SD), breaths/minb | |||
| Age 2-11 mo | |||
| <50 | 1 (0.2) | 0 | 1 (0.1) |
| 50-59 | 133 (23.6) | 146 (26.0) | 279 (24.8) |
| ≥60 | 62 (11.0) | 50 (8.9) | 112 (9.9) |
| Age 12-59 mo | |||
| <40 | 0 | 0 | 0 |
| 40-49 | 234 (41.5) | 233 (41.5) | 467 (41.5) |
| ≥50 | 134 (23.8) | 133 (23.7) | 267 (23.7) |
| Oxygen saturation, %b | |||
| <90 | 0 | 0 | 0 |
| 90-92 | 0 | 0 | 0 |
| ≥93 | 564 (100) | 562 (100) | 1126 (100) |
| Axillary temperature, °Cb | |||
| <38 | 386 (68.4) | 405 (72.1) | 791 (70.2) |
| ≥38 | 178 (31.6) | 157 (27.9) | 335 (29.8) |
| Heart rate, mean (SD), beats/mina | 142.3 (18.1) | 142.4 (17.2) | 142.4 (17.6) |
| Pneumococcal vaccine | |||
| Received 3 doses | 298 (52.8) | 321 (57.1) | 619 (55.0) |
| Received <3 doses or unknown | 266 (47.2) | 241 (42.9) | 507 (45.0) |
| Pentavalent vaccine | |||
| Received 3 doses | 301 (53.4) | 319 (56.8) | 620 (55.1) |
| Received <3 doses or unknown | 263 (46.6) | 243 (43.2) | 506 (44.9) |
| Caregiver assessment at enrollment | |||
| Fevera | |||
| Yes | 476 (84.4) | 469 (83.5) | 945 (83.9) |
| No. of days, mean (SD) | 2.7 (1.1) | 2.8 (1.4) | 2.7 (1.2) |
| Cougha | |||
| Yes | 546 (96.8) | 547 (97.3) | 1093 (97.1) |
| No. of days, mean (SD) | 2.9 (1.2) | 3.1 (1.5) | 3.0 (1.4) |
| Difficult breathinga | |||
| Yes | 180 (31.9) | 180 (32.0) | 360 (32.0) |
| No. of days, mean (SD) | 2.5 (0.9) | 2.6 (1.3) | 2.5 (1.1) |
a
Data not available for all randomized children.
b
Larger value between screening and enrollment visits.