Figure 1. Conceptual Model of Biological Embedding of Adversity With Mediating Associations.
ACEs indicates adverse childhood events; S1, scan 1; T2, time 2; T3, time 3. a1 Represents the association between early ACEs and prefrontal subregion volumes; a2, the association between early ACEs and emotion/behaviors; b1, the association between prefrontal subregion volumes and physical/emotional health outcomes; b2, the association between emotion/behaviors and physical/emotional health outcomes; c′, the direct effect between early ACEs and physical/emotional health outcomes; d1,2, the association between prefrontal subregion volumes and emotion/behaviors.