Table 4. Case Fatality of First Bleeding Event by Bleeding Type, Sex, and Age Group for Each of the 3 Cohortsa.
| Bleeding Events | Baseline Cohort | Non–High-Risk Cohort | Nonmedication Cohort | |||
|---|---|---|---|---|---|---|
| No. With Fatal Event/Total No. of Events | Case Fatality, % (95% CI) | No. With Fatal Event/Total No. of Events | Case Fatality, % (95% CI) | No. With Fatal Event/Total No. of Events | Case Fatality, % (95% CI) | |
| Gastrointestinal Bleeding | ||||||
| Men | ||||||
| Aged 70-79 y | 12/165 | 7.3 (4.2-12.3) | 4/95 | 4.2 (1.6-10.3) | 4/74 | 5.4 (2.1-13.1) |
| Aged 60-69 y | 21/401 | 5.2 (3.5-7.9) | 14/257 | 5.4 (3.3-8.9) | 12/195 | 6.2 (3.6-10.4) |
| Aged 50-59 y | 19/541 | 3.5 (2.3-5.4) | 13/372 | 3.5 (2.1-5.9) | 11/272 | 4.0 (2.3-7.1) |
| Aged 40-49 y | 9/472 | 1.9 (1.0-3.6) | 4/346 | 1.2 (0.5-2.9) | 4/246 | 1.6 (0.6-4.1) |
| Aged 30-39 y | 1/138 | 0.7 (0.1-4.0) | 1/118 | 0.8 (0.1-4.6) | 1/83 | 1.2 (0.2-6.5) |
| Subtotal | 62/1717 | 3.6 (2.8-4.6) | 36/1188 | 3.0 (2.2-4.2) | 32/870 | 3.7 (2.6-5.1) |
| Women | ||||||
| Aged 70-79 y | 10/165 | 6.1 (3.3-10.8) | 5/105 | 4.8 (2.1-10.7) | 4/85 | 4.7 (1.8-11.5) |
| Aged 60-69 y | 11/389 | 2.8 (1.6-5.0) | 10/254 | 3.9 (2.2-7.1) | 8/200 | 4.0 (2.0-7.7) |
| Aged 50-59 y | 10/396 | 2.5 (1.4-4.6) | 8/290 | 2.8 (1.4-5.3) | 6/207 | 2.9 (1.3-6.2) |
| Aged 40-49 y | 4/216 | 1.9 (0.7-4.7) | 3/156 | 1.9 (0.7-5.5) | 1/94 | 1.1 (0.2-5.8) |
| Aged 30-39 y | 1/27 | 3.7 (0.7-18.3) | 1/27 | 3.7 (0.7-18.3) | 1/17 | 5.9 (1.0-27.0) |
| Subtotal | 36/1193 | 3.0 (2.2-4.1) | 27/832 | 3.2 (2.2-4.7) | 20/603 | 3.3 (2.2-5.1) |
| Total | 98/2910 | 3.4 (2.8-4.1) | 63/1559 | 4.0 (3.2-5.1) | 52/1121 | 4.6 (3.6-6.0) |
| Intracerebral Bleeding | ||||||
| Men | ||||||
| Aged 70-79 y | 10/30 | 33.3 (19.2-51.2) | 5/19 | 26.3 (11.8-48.8) | 3/15 | 20.0 (7.0-45.2) |
| Aged 60-69 y | 18/73 | 24.7 (16.2-35.6) | 10/54 | 18.5 (10.4-30.8) | 8/45 | 17.8 (9.3-31.3) |
| Aged 50-59 y | 26/96 | 27.1 (19.2-36.7) | 17/76 | 22.4 (14.5-32.9) | 13/65 | 20.0 (12.1-31.3) |
| Aged 40-49 y | 21/50 | 42.0 (29.4-55.8) | 17/44 | 38.6 (25.7-53.4) | 15/35 | 42.9 (28.0-59.1) |
| Aged 30-39 y | 4/19 | 21.1 (8.5-43.3) | 4/15 | 26.7 (10.9-52.0) | 3/12 | 25.0 (8.9-53.2) |
| Subtotal | 79/268 | 29.5 (24.3-35.2) | 53/208 | 25.5 (20.0-31.8) | 42/172 | 24.4 (18.6-31.4) |
| Women | ||||||
| Aged 70-79 y | 24/51 | 47.1 (34.1-60.5) | 17/37 | 45.9 (31.0-61.6) | 12/30 | 40.0 (24.6-57.7) |
| Aged 60-69 y | 23/73 | 31.5 (22.0-42.9) | 17/52 | 32.7 (21.5-46.2) | 14/40 | 35.0 (22.1-50.5) |
| Aged 50-59 y | 16/85 | 18.8 (11.9-28.4) | 15/75 | 20.0 (12.5-30.4) | 10/53 | 18.9 (10.6-31.4) |
| Aged 40-49 y | 11/39 | 28.2 (16.5-43.8) | 11/33 | 33.3 (19.8-50.4) | 7/25 | 28.0 (14.3-47.6) |
| Aged 30-39 y | 0/2 | 0.0 (0.0-65.8) | 0/2 | 0.0 (0.0-65.8) | 0/2 | 0.0 (0.0-65.8) |
| Subtotal | 74/250 | 29.6 (24.3-35.5) | 60/199 | 30.2 (24.2-36.9) | 43/150 | 28.7 (22.0-36.4) |
| Total | 153/518 | 29.5 (25.8-33.6) | 113/361 | 31.3 (26.7-36.3) | 85/270 | 31.5 (26.2-37.2) |
| Other Bleeding | ||||||
| Men | ||||||
| Aged 70-79 y | 1/20 | 5.0 (0.9-23.6) | 1/9 | 11.1 (2.0-43.5) | 0/7 | 0.0 (0.0-35.4) |
| Aged 60-69 y | 4/67 | 6.0 (2.3-14.4) | 1/44 | 2.3 (0.4-11.8) | 1/33 | 3.0 (0.5-15.3) |
| Aged 50-59 y | 6/103 | 5.8 (2.7-12.1) | 3/76 | 3.9 (1.4-11.0) | 2/58 | 3.4 (1.0-11.7) |
| Aged 40-49 y | 4/77 | 5.2 (2.0-12.6) | 3/51 | 5.9 (2.0-15.9) | 1/37 | 2.7 (0.5-13.8) |
| Aged 30-39 y | 0/18 | 0.0 (0.0-17.6) | 0/17 | 0.0 (0.0-18.4) | 0/14 | 0.0 (0.0-21.5) |
| Subtotal | 15/285 | 5.3 (3.2-8.5) | 8/197 | 4.1 (2.1-7.8) | 4/149 | 2.7 (1.0-6.7) |
| Women | ||||||
| Aged 70-79 y | 0/38 | 0.0 (0.0-9.2) | 0/20 | 0.0 (0.0-16.1) | 0/17 | 0.0 (0.0-18.4) |
| Aged 60-69 y | 4/68 | 5.9 (2.3-14.2) | 2/53 | 3.8 (1.0-12.8) | 2/46 | 4.3 (1.2-14.5) |
| Aged 50-59 y | 2/94 | 2.1 (0.6-7.4) | 2/70 | 2.9 (0.8-9.8) | 2/51 | 3.9 (1.1-13.2) |
| Aged 40-49 y | 2/58 | 3.4 (1.0-11.7) | 2/43 | 4.7 (1.3-15.5) | 2/28 | 7.1 (2.0-22.6) |
| Aged 30-39 y | 0/5 | 0.0 (0.0-43.4) | 0/4 | 0.0 (0.0-49.0) | 0/4 | 0.0 (0.0-49.0) |
| Subtotal | 8/263 | 3.0 (1.5-5.9) | 6/190 | 3.2 (1.5-6.7) | 6/146 | 4.1 (1.9-8.7) |
| Total | 23/548 | 4.2 (2.8-6.2) | 14/360 | 3.9 (2.3-6.4) | 10/275 | 3.6 (2.0-6.6) |
| Any Bleeding | ||||||
| Men | ||||||
| Aged 70-79 y | 23/215 | 10.7 (7.2-15.5) | 10/123 | 8.1 (4.5-14.3) | 7/96 | 7.3 (3.6-14.3) |
| Aged 60-69 y | 43/541 | 7.9 (6.0-10.5) | 25/355 | 7.0 (4.8-10.2) | 21/273 | 7.7 (5.1-11.5) |
| Aged 50-59 y | 51/740 | 6.9 (5.3-8.9) | 33/524 | 6.3 (4.5-8.7) | 26/395 | 6.6 (4.5-9.5) |
| Aged 40-49 y | 34/599 | 5.7 (4.1-7.8) | 24/441 | 5.4 (3.7-8.0) | 20/318 | 6.3 (4.1-9.5) |
| Aged 30-39 y | 5/175 | 2.9 (1.2-6.5) | 5/150 | 3.3 (1.4-7.6) | 4/109 | 3.7 (1.4-9.1) |
| Subtotal | 156/2270 | 6.9 (5.9-8.0) | 97/1593 | 6.1 (5.0-7.4) | 78/1191 | 6.5 (5.3-8.1) |
| Women | ||||||
| Aged 70-79 y | 34/254 | 13.4 (9.7-18.1) | 22/162 | 13.6 (9.1-19.7) | 16/132 | 12.1 (7.6-18.8) |
| Aged 60-69 y | 38/530 | 7.2 (5.3-9.7) | 29/359 | 8.1 (5.7-11.4) | 24/286 | 8.4 (5.7-12.2) |
| Aged 50-59 y | 28/575 | 4.9 (3.4-6.9) | 25/435 | 5.7 (3.9-8.3) | 18/311 | 5.8 (3.7-9.0) |
| Aged 40-49 y | 17/313 | 5.4 (3.4-8.5) | 16/232 | 6.9 (4.3-10.9) | 10/147 | 6.8 (3.7-12.1) |
| Aged 30-39 y | 1/34 | 2.9 (0.5-14.9) | 1/27 | 3.7 (0.7-18.3) | 1/23 | 4.3 (0.8-21.0) |
| Subtotal | 118/1706 | 6.9 (5.8-8.2) | 93/1215 | 7.7 (6.3-9.3) | 69/899 | 7.7 (6.1-9.6) |
| Total | 274/3976 | 6.9 (6.1-7.7) | 190/2268 | 8.4 (7.3-9.6) | 147/1666 | 8.8 (7.6-10.3) |
a
See Methods section of text for descriptions of baseline, non–high-risk, and nonmedication cohorts.