Table 3. Metastasis by 0.5-mm and 1.0-mm Increments After Plaque Radiotherapy for Small Choroidal Melanoma (N = 1780).

Tumor Size	No. (%)		Kaplan-Meier Estimates, No. of Affected Patients/No. of Unaffected Patients (%) [95% CI]
	Total Patients (N = 1780)	Patients With Metastasis (n = 91)	1-y	3-y	5-y	10-y	15-y	20-y	P Valuea
Using 0.5-mm increments
0.5-1.0	6 (0.3)	1 (1)	0/5	0/4	1/2 (25.0) [3.9-87.2]b	1/1 (25.0) [3.9-87.2]b	1/1 (25.0) [3.9-87.2]b	NE	.003
1.1-1.5 mm	29 (1.6)	0	0/23	0/18	0/16	0/8	0/6	0/5
1.6-2.0 mm	231 (13.0)	8 (9)	2/197 (0.9) [0.2-3.7]	4/157 (2.1) [0.8-5.5]	5/113 (2.9) [1.2-7.1]	7/39 (6.7) [2.8-15.6]	8/17 (10.3) [4.3-23.6]	8/6 (10.3) [4.3-23.6]
2.1-2.5 mm	521 (29.3)	17 (19)	1/462 (0.2) [0.03-1.4]	3/337 (0.7) [0.2-2.2]	10/227 (3.3) [1.8-6.1]	15/88 (6.3) [3.7-10.3]	17/33 (8.5) [5.0-14.2]	17/10 (8.5) [5.0-14.2]
2.6-3.0 mm	615 (34.6)	39 (43)	1/538 (0.2) [0.02-1.2]	10/383 (2.1) [1.1-3.8]	19/264 (4.8) [3.0--7.5]	29/110 (9.7) [6.6-14.0]	37/34 (21.4) [14.1-31.6]	39/10 (27.3) [17.8-40.5]
>3.0 mm	377 (21.2)	26 (29)	0/335	7/228 (2.5) [1.2-5.1]	15/140 (6.9) [4.2-11.4]	22/44 (13.4) [8.7-20.4]	25/6 (28.0) [13.9-51.4]	26/4 (42.4) [19.7-75.0]
Using 1-mm increments
0-1.0 mm	7 (0.4)	1 (1)	0/6	0/4	1/2 (25.0) [3.9-87.2]	1/1 (25.0) [3.9- 87.2]	1/1 (25.0) [3.9-87.2]	NE	.01
1.1-2.0 mm	260 (14.6)	8 (9)	2/220 (0.8) [0.2-3.3]	4/175 (1.9) [0.7-4.9]	5/129 (2.6) [1.1-6.3]	7/47 (5.9) [2.50-13.5]	8/23 (8.8) [3.7-20.0]	8/11 (8.8) [3.7-20.0]
2.1-3.0 mm	1136 (63.8)	56 (62)	2/1000 (0.8) [0.05-0.7]	13/720 (1.4) [0.8-2.5]	29/421 (4.1) [2.8-5.9]	44/198 (8.1) [5.9-11.0]	54/67 (15.5) [11.0 – 21.6]	56/20 (19.3) [13.2 – 27.7]
>3.0 mm	377 (21.2)	26 (29)	0/335	7/228 (2.5) [1.2-5.1]	15/140 (6.9) [4.2-11.4]	22/44 (13.4) [8.7-20.4]	25/6 (28.0) [13.9-51.4]	26/4 (42.4) [19.7-75.0]
All tumors	1780 (100)	91 (100)	4/1561 (0.2) [0.1-0.6]	24/1127 (1.7) [1.1-2.6]	50/762 (4.5) [3.4-5.9]	74/290 (8.8) [6.9-11.1]	88/97 (16.0) [12.1-20.8]	91/35 (19.5) [14.5-25.9]

Abbreviation: NE, not estimable.

^a Log-rank test.

^b Diffuse configuration.