Table 5. Clinical Features Associated With Death After Plaque Radiotherapy for Small Choroidal Melanoma (N = 1780).
| Feature | No. (%) | Univariable Analysis | Multivariable Analysis | |||
|---|---|---|---|---|---|---|
| Death (n = 80) | No Death (n = 1700) | P Value | Relative Risk (95% CI) | P Value | Relative Risk (95% CI) | |
| Age, mean (SD), y | 63 (14) | 58 (14) | <.001 | 1.66 (1.37-2.00)a | <.001 | 1.60 (1.33-1.93)a |
| Tumor quadrant | ||||||
| Macula vs nasalb | 26 (33) | 515 (30.3) | .03 | 3.76 (1.14-12.4) | NA | NA |
| Superior vs nasalb | 21 (26) | 390 (22.9) | .02 | 4.04 (1.21-13.6) | NA | NA |
| Inferior vs nasalb | 17 (21) | 265 (15.9) | .01 | 4.81 (1.41-16.4) | NA | NA |
| Tumor basal diameter, mm | ||||||
| Mean (SD) | 9.5 (2.9) | 8.7 (2.9) | .01 | 1.11 (1.03-1.19)c | NA | NA |
| Median (range) | 9.0 (5.0-17.0) | 8.0 (2.0-20.0) | NA | NA | ||
| Tumor thickness, mm | ||||||
| Mean (SD) | 2.8 (0.5) | 2.6 (0.5) | <.001 | 2.37 (1.44-3.89)c | .01 | 2.03 (1.24-3.31)c |
| Median (range) | 3.0 (0.5-3.4) | 2.7 (0.2-3.4) | ||||
| Subretinal fluid in 1 quadrant | 23 (29) | 362 (21.3) | .03 | 2.19 (1.08-4.42) | NA | NA |
| Plaque type (iridium vs iodine 125b) | 5 (6) | 32 (1.8) | .04 | 2.59 (1.03-6.49) | NA | NA |
Abbreviation: NA, not applicable.
a
Per 10-year increase.
b
Nasal is the reference category for these comparisons.
c
Per 1-mm increase.