Table. Baseline Characteristics by Randomization Group Among 300 Patients With Depression After Acute Coronary Syndrome.
| Characteristics | Escitalopram (n = 149) | Placebo (n = 151) |
|---|---|---|
| Demographics | ||
| Age, mean (SD), y | 60.0 (11.2) | 60.1 (10.5) |
| Men, No. (%) | 88 (59.1) | 93 (61.6) |
| Education, mean (SD), y | 9.4 (4.2) | 9.2 (4.1) |
| Unmarried, No. (%) | 18 (12.1) | 29 (19.2) |
| Living alone, No. (%) | 12 (8.1) | 16 (10.6) |
| Rented accommodation, No. (%) | 21 (14.1) | 34 (22.5) |
| Unemployed, No. (%) | 71 (47.7) | 73 (48.3) |
| Depression | ||
| Beck Depression Inventory scorea | 16 (13-22) | 17 (14-23) |
| Mean (SD) | 18.8 (8.3) | 19.2 (7.7) |
| Median (IQR) | 16 (13-22) | 17 (14-23) |
| DSM-IV diagnosis of major depressive disorder, No. (%) | 85 (57.0) | 84 (55.6) |
| Previous depression, No. (%) | 6 (4.0) | 7 (4.6) |
| Cardiac risk factors, No. (%) | ||
| Hypertension | 90 (60.4) | 94 (62.3) |
| Diabetes mellitus | 44 (29.5) | 41 (27.2) |
| Hypercholesterolemia | 73 (49.0) | 71 (47.0) |
| Obesity | 59 (39.6) | 65 (43.0) |
| Current smoker | 43 (28.9) | 42 (27.8) |
| Previous acute coronary syndrome | 8 (5.4) | 11 (7.3) |
| Family history of acute coronary syndrome | 9 (6.0) | 8 (5.3) |
| Current cardiac status | ||
| Acute coronary syndrome diagnosis of myocardial infarction, No. (%) | 92 (61.7) | 92 (60.9) |
| Killip class >1, No. (%)b | 24 (16.1) | 35 (23.2) |
| NYHA class >I, No. (%)c | 15 (10.1) | 18 (11.9) |
| LVEF, mean (SD), % | 60.4 (11.0) | 61.9 (10.4) |
| LVEF <55%, No. (%) | 34 (22.8) | 33 (21.9) |
| QTc duration, mean (SD), ms | 433.3 (39.7) | 438.9 (38.3) |
| Peak troponin I, mean (SD), mg/dL | 6.7 (8.5) | 7.7 (8.0) |
| Peak creatine kinase MB fraction, mean (SD), mg/dL | 17.2 (22.0) | 16.3 (20.8) |
Abbreviations: DSM-IV, Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition); IQR, interquartile range; LVEF, left ventricular ejection fraction.
a
The Beck Depression Inventory consists of 21 items with a total score ranging from 0 to 63, with higher scores indicating more severe depressive symptoms.
b
Killip class is ranked from 1 to 4, with higher rank indicating more severe clinical signs of heart failure.
c
New York Heart Association (NYHA) class is ranked from I to IV, with higher rank indicating more severe limitation of activity due to symptoms.