Skip to main content
. 2018 Jul 24;320(4):350–357. doi: 10.1001/jama.2018.9422

Table. Baseline Characteristics by Randomization Group Among 300 Patients With Depression After Acute Coronary Syndrome.

Characteristics Escitalopram (n = 149) Placebo (n = 151)
Demographics
Age, mean (SD), y 60.0 (11.2) 60.1 (10.5)
Men, No. (%) 88 (59.1) 93 (61.6)
Education, mean (SD), y 9.4 (4.2) 9.2 (4.1)
Unmarried, No. (%) 18 (12.1) 29 (19.2)
Living alone, No. (%) 12 (8.1) 16 (10.6)
Rented accommodation, No. (%) 21 (14.1) 34 (22.5)
Unemployed, No. (%) 71 (47.7) 73 (48.3)
Depression
Beck Depression Inventory scorea 16 (13-22) 17 (14-23)
Mean (SD) 18.8 (8.3) 19.2 (7.7)
Median (IQR) 16 (13-22) 17 (14-23)
DSM-IV diagnosis of major depressive disorder, No. (%) 85 (57.0) 84 (55.6)
Previous depression, No. (%) 6 (4.0) 7 (4.6)
Cardiac risk factors, No. (%)
Hypertension 90 (60.4) 94 (62.3)
Diabetes mellitus 44 (29.5) 41 (27.2)
Hypercholesterolemia 73 (49.0) 71 (47.0)
Obesity 59 (39.6) 65 (43.0)
Current smoker 43 (28.9) 42 (27.8)
Previous acute coronary syndrome 8 (5.4) 11 (7.3)
Family history of acute coronary syndrome 9 (6.0) 8 (5.3)
Current cardiac status
Acute coronary syndrome diagnosis of myocardial infarction, No. (%) 92 (61.7) 92 (60.9)
Killip class >1, No. (%)b 24 (16.1) 35 (23.2)
NYHA class >I, No. (%)c 15 (10.1) 18 (11.9)
LVEF, mean (SD), % 60.4 (11.0) 61.9 (10.4)
LVEF <55%, No. (%) 34 (22.8) 33 (21.9)
QTc duration, mean (SD), ms 433.3 (39.7) 438.9 (38.3)
Peak troponin I, mean (SD), mg/dL 6.7 (8.5) 7.7 (8.0)
Peak creatine kinase MB fraction, mean (SD), mg/dL 17.2 (22.0) 16.3 (20.8)

Abbreviations: DSM-IV, Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition); IQR, interquartile range; LVEF, left ventricular ejection fraction.

a

The Beck Depression Inventory consists of 21 items with a total score ranging from 0 to 63, with higher scores indicating more severe depressive symptoms.

b

Killip class is ranked from 1 to 4, with higher rank indicating more severe clinical signs of heart failure.

c

New York Heart Association (NYHA) class is ranked from I to IV, with higher rank indicating more severe limitation of activity due to symptoms.