Table 1:
Baseline characteristics of the MDACC molecular cohort classified by age
| Age (years) | 18–29 | 30–39 | 40–49 | 50–59 | 60–69 | ≥ 70 | P |
|---|---|---|---|---|---|---|---|
| N (%) | 46 (2) | 177 (9) | 411 (22) | 605 (32) | 454 (24) | 184 (10) | |
| Gender | |||||||
| Male | 20 (44) | 94 (53) | 208 (51) | 35 (58) | 263 (58) | 123 (67) | 0.002 |
| Female | 26 (57) | 83 (47) | 203 (49) | 255 (42) | 191 (42) | 61 (33) | |
| Race/Ethnicity | |||||||
| Caucasian | 33 (72) | 121 (68) | 299 (73) | 456 (75) | 332 (73) | 146 (80) | 0.094* |
| African American | 2 (4) | 20 (11) | 31 (8) | 68 (11) | 45 (10) | 16 (9) | |
| Hispanic | 9 (20) | 22 (12) | 49 (12) | 54 (9) | 49 (11) | 16 (9) | |
| Other | 2 (4) | 14 (8) | 32 (8) | 27 (5) | 28 (6) | 6 (3) | |
| Location (N=1876, 99% known) | |||||||
| Right Colon | 8 (17) | 41 (23) | 109 (27) | 192 (33) | 183 (40) | 71 (39) | < 0.001 |
| Left Colon | 24 (52) | 94 (53) | 209 (51) | 275 (46) | 179 (39) | 69 (38) | |
| Rectum | 14 (30) | 42 (24) | 93 (23) | 138 (23) | 92 (20) | 43 (23) | |
| Metastatic Disease | |||||||
| Metachronous | 14 (30) | 49 (28) | 133 (32) | 206 (34) | 183 (40) | 77 (42) | 0.009 |
| Synchronous | 32 (70) | 128 (72) | 278 (68) | 399 (66) | 271 (60) | 107 (58) | |
| Histology (N=1871, 99% known) | |||||||
| Non-mucinous, Non-signet ring Adenocarcinoma | 35 (80) | 146 (83) | 344 (84) | 506 (84) | 367 (81) | 151 (81) | 0.60 |
| Mucinous | 6 (13) | 25 (14) | 61 (15) | 84 (14) | 72 (16) | 29 (16) | |
| Signet ring | 3 (7) | 5 (3) | 5 (1) | 14 (2) | 14 (3) | 4 (2) | |
| MSI-H (N=1525, 81% known) | 3 (7) | 12 (8) | 23 (3) | 11 (2) | 13 (4) | 6 (4) | 0.038 |
Values represent number followed in brackets by % of known patients. N = number.
*
Analysis of race/ethnicity excluding “other” yielded P=0.19