Table 2. Linear Regression for Negative Control Polygenic Scores.

Negative Control Phenotype	Discovery Sample, No.	SNPs, No.	P Valuea	Standardized Coefficient, b (95% CI)	Permutation P Valueb
Alcoholic liver disease	361 194	126 650	.35	−0.027 (−0.056 to 0.001)	.18
Family history of Alzheimer disease	314 278	8591	.01	−0.032 (−0.060 to −0.004)	.09
Poor self-rated health	111 749	96 877	.22	0.057 (0.028 to 0.086)	<.001
Inflammatory bowel disease	34 652	103 729	.24	0.017 (−0.011 to 0.045)	.52
Osteoporosis	142 487	60 289	.09	0.006 (−0.024 to 0.035)	.99
Parkinson disease	5691	3744	.01	−0.019 (−0.047 to 0.009)	.52

Abbreviation: SNP, single-nucleotide polymorphism.

^aP value threshold for the best-fit polygenic genic.

^bP value estimate after permutation (10 000 times).